SH2D3A and ITGB8

		SH2D3A	ITGB8
Description		SH2 domain containing 3A	integrin subunit beta 8
Image		No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 34103634 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BCAR1 CENPB EGFR ERBB2 ERBB3 GAB1 ITGB8 NXF1 RRM1	11 interacting genes: CHN2 HOXA1 ITGAV PSPH RAPGEF5 RRAGD SH2D3A SP4 TGFB1 TOMM7 VTN
Entrez ID		10045	3696
HPRD ID		05283	05001
Ensembl ID		ENSG00000125731	ENSG00000105855
Uniprot IDs		A8K2M8 Q9BRG2	P26012 Q9BUG9
PDB IDs			6DJP 6OM1 6OM2 6UJA 6UJB 6UJC
Enriched GO Terms of Interacting Partners?
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