BCL2L11 and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 16697956)
511

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		BCL2L11	BCL2L2
Description		BCL2 like 11	BCL2 like 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Endomembrane System Extrinsic Component Of Membrane Bcl-2 Family Protein Complex	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding
	Biological Process	In Utero Embryonic Development B Cell Homeostasis Kidney Development Myeloid Cell Homeostasis Apoptotic Process Meiosis I Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Autophagy In Response To ER Overload Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Animal Organ Morphogenesis Thymocyte Apoptotic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To Amyloid-beta Positive Regulation Of Fibroblast Apoptotic Process	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF1 fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling FOXO-mediated transcription of cell death genes
Drugs			Navitoclax
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body shape index ( 34021172) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic granulomatosis with polyangiitis ( 31719529) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 21151127) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 28869590) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Urinary albumin-to-creatinine ratio ( 32600054) Vitiligo ( 27723757) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BTK DTX2 DYNLL1 DYNLL2 FEM1C FGL1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D MKRN3 NPHP1 PEX19 RACK1 RIOK3 SMARCB1 TRIM2 UBQLN2 USHBP1 VDAC1 YWHAB	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		10018	599
HPRD ID		04828	03569
Ensembl ID		ENSG00000153094	ENSG00000129473
Uniprot IDs		A0A0A0MRE7 A0A0C4DH20 O43521	Q92843
PDB IDs		1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW 5AGX 5C3G 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX2 5VX3 5WOS 6QFI 6RJP 6TQQ 6UA3 6UAB 6X8O	1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?