PDZD11 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CD79B	CD79b molecule	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Polatuzumab vedotin	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
Novel	EDEM1	ER degradation enhancing alpha-mannosidase like protein 1	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Novel	GDPD2	glycerophosphodiester phosphodiesterase domain containing 2
Novel	KIF4A	kinesin family member 4A	MHC class II antigen presentation Recycling pathway of L1 Recycling pathway of L1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Novel	MYO1F	myosin IF
Novel	NLGN3	neuroligin 3	Neurexins and neuroligins Neurexins and neuroligins
Novel	RAB11FIP2	RAB11 family interacting protein 2	Vasopressin regulates renal water homeostasis via Aquaporins
Novel	SMG8	SMG8 nonsense mediated mRNA decay factor	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	SNX12	sorting nexin 12
Novel	TAF1	TATA-box binding protein associated factor 1	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Novel	TEX11	testis expressed 11
Novel	ZMYM3	zinc finger MYM-type containing 3
	ATP2B2	ATPase plasma membrane Ca2+ transporting 2	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Halothane Desflurane
	ATP7A	ATPase copper transporting alpha	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Distal hereditary motor neuropathies (dHMN) Menkes disease (MD); Menkes kinky hair syndrome Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
	MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	Nephrin family interactions
	PLEKHA5	pleckstrin homology domain containing A5	Synthesis of PIPs at the plasma membrane
	SIGMAR1	sigma non-opioid intracellular receptor 1	Potential therapeutics for SARS	Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine

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