PDZD11 and EDEM1

Data Source:
HPRD (in vitro, in vivo)

		PDZD11	EDEM1
Description		PDZ domain containing 11	ER degradation enhancing alpha-mannosidase like protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cell-cell Junction Adherens Junction Basolateral Plasma Membrane Synapse Pore Complex Presynapse	Endoplasmic Reticulum Aggresome Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Biotin Metabolic Process Neurotransmitter Secretion Pantothenate Metabolic Process Antimicrobial Humoral Response Ion Transmembrane Transport Maintenance Of Epithelial Cell Apical/basal Polarity Pore Complex Assembly Transmembrane Transport Protein Localization To Basolateral Plasma Membrane	Carbohydrate Metabolic Process Ubiquitin-dependent ERAD Pathway IRE1-mediated Unfolded Protein Response Trimming Of Terminal Mannose On C Branch Protein Targeting To ER Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mannose Trimming Involved In Glycoprotein ERAD Pathway
Pathways		Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS			Diverticular disease ( 30177863) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		5 interacting genes: ATP2B2 ATP7A MAGI2 PLEKHA5 SIGMAR1	1 interacting genes: CANX
Entrez ID		51248	9695
HPRD ID		06622	09644
Ensembl ID		ENSG00000120509	ENSG00000134109
Uniprot IDs		Q5EBL8	A0A024R2D5 Q92611
PDB IDs
Enriched GO Terms of Interacting Partners?
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