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CDC6 and CDT1
Data Source:
HPRD
(in vitro, in vivo)
CDC6
CDT1
Description
cell division cycle 6
chromatin licensing and DNA replication factor 1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Intercellular Bridge
Spindle Midzone
Mitotic Spindle
Kinetochore
Condensed Chromosome Kinetochore
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
Molecular Function
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Kinase Binding
DNA Binding
Chromatin Binding
Protein Binding
DNA Polymerase Binding
Biological Process
DNA Replication Checkpoint
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Traversing Start Control Point Of Mitotic Cell Cycle
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Cytokinesis
Mitotic DNA Replication Checkpoint
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Cell Division
Positive Regulation Of Chromosome Segregation
Cellular Response To Vasopressin
Cellular Response To Angiotensin
DNA Replication Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Chromosome Segregation
Regulation Of DNA-dependent DNA Replication Initiation
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Chromosome Organization
Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of Chromatin Binding
Positive Regulation Of DNA Replication
Cell Division
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Kinetochore Organization
DNA Replication Preinitiation Complex Assembly
Response To Sorbitol
Deactivation Of Mitotic Spindle Assembly Checkpoint
Regulation Of DNA Replication Origin Binding
Negative Regulation Of Protein Localization To Kinetochore
Positive Regulation Of Protein Localization To Kinetochore
Positive Regulation Of DNA-dependent DNA Replication
Pathways
Transcription of E2F targets under negative control by DREAM complex
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
G1/S-Specific Transcription
Drugs
Diseases
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS
Asthma (
31619474
)
Glycated hemoglobin levels (
28898252
)
Hair color (
26926045
)
Hemoglobin A1c levels (
29403010
)
Mean corpuscular hemoglobin concentration (
29403010
20139978
28017375
)
Mean corpuscular volume (
29403010
)
Interacting Genes
38 interacting genes:
AKAP8L
ATM
ATRIP
B3GALNT1
CCNA2
CCNB1
CCNE1
CCNF
CDC14A
CDC20
CDK1
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDT1
FZR1
KAT7
MCM10
MCM2
MCM3
MCM7
MYC
ORC1
ORC2
ORC3
ORC5
ORC6
PCNA
PPP2R3A
PPP2R3B
PSKH1
RPS27A
SQSTM1
TERF1
UBE2K
UBR1
28 interacting genes:
ANAPC7
BAZ1B
CCNA2
CCNB1
CDC20
CDC23
CDC5L
CDC6
CDK1
CDK2
DTL
EP300
FBXO31
FOXO3
FZR1
GMNN
KAT2B
MAPK14
MCM2
MCM4
MCM6
NPM1
ORC1
ORC2
PCNA
SKP2
SMARCA5
UBB
Entrez ID
990
81620
HPRD ID
04022
06900
Ensembl ID
ENSG00000094804
ENSG00000167513
Uniprot IDs
A0A024R1S2
Q99741
Q9H211
PDB IDs
2CCH
2CCI
4I5L
4I5N
2LE8
2WVR
6QCG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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