CDC6 and PPP2R3B

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vivo, two hybrid, in vitro)

		CDC6	PPP2R3B
Description		cell division cycle 6	protein phosphatase 2 regulatory subunit B''beta
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	Protein Dephosphorylation Cell Cycle Arrest Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Asthma ( 31619474)
Interacting Genes		38 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1	9 interacting genes: CDC6 DUSP12 HGS NAA10 NOD2 PPP2CA PPP2R1A PPP2R1B TMEM14B
Entrez ID		990	28227
HPRD ID		04022	02276
Ensembl ID		ENSG00000094804	ENSG00000167393
Uniprot IDs		A0A024R1S2 Q99741	Q9Y5P8
PDB IDs		2CCH 2CCI 4I5L 4I5N	4I5L 4I5N 4MEW
Enriched GO Terms of Interacting Partners?
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