CDC6 and RPS27A

Data Source:
HPRD (in vivo)

		CDC6	RPS27A
Description		cell division cycle 6	ribosomal protein S27a
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Endocytic Vesicle Membrane Vesicle Host Cell Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Protein Tag Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Activation Of MAPK Activity Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Protein Targeting To Peroxisome Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Wnt Signaling Pathway Endosomal Transport Protein Ubiquitination Protein Deubiquitination Viral Life Cycle Virion Assembly Viral Transcription Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process Translesion Synthesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Catabolic Process Nucleotide-excision Repair, DNA Incision TRIF-dependent Toll-like Receptor Signaling Pathway Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Transmembrane Transport Membrane Organization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Global Genome Nucleotide-excision Repair Error-free Translesion Synthesis Intracellular Transport Of Virus
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Viral mRNA Translation Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Selenocysteine synthesis Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport Circadian Clock TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Major pathway of rRNA processing in the nucleolus and cytosol Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Response of EIF2AK4 (GCN2) to amino acid deficiency Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Maturation of protein E Maturation of protein E Negative regulation of FLT3 FLT3 signaling by CBL mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474)
Interacting Genes		38 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1	38 interacting genes: ACVR1 APP BMPR1B CALCOCO2 CDC6 CDK11B DAZAP2 DESI1 DNAJB2 EPN3 FAM168A FSHR GGA1 GGA3 KANSL3 LITAF MAST2 MDM2 MTURN PAXIP1 PLEKHB2 PLSCR4 POLH PTEN RABGEF1 RAD23A RNF11 SMAD1 SMAD2 SMAD4 SMURF1 SMURF2 TGFBR1 TRAF6 UBQLN1 UBQLN2 WBP2 ZNF512B
Entrez ID		990	6233
HPRD ID		04022	01878
Ensembl ID		ENSG00000094804	ENSG00000143947
Uniprot IDs		A0A024R1S2 Q99741	B2RDW1 P62979
PDB IDs		2CCH 2CCI 4I5L 4I5N	2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6DC6 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6J99 6KFP 6KG6 6KIU 6KIV 6KIW 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SQO 6SQR 6SQS 6XA1 6Y0G 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZON 6ZP4 6ZVH 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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