KIAA0753 and RNF6

Data Source:
BioGRID (two hybrid)

		KIAA0753	RNF6
Description		KIAA0753	ring finger protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm PML Body Axon Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Centriole Replication Protein Localization To Centrosome	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Familial lung cancer ( 29924316) LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418)	Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 30297969 32499647 30718926 28869590) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		20 interacting genes: AARD BHLHA9 BRPF1 C1orf109 CCHCR1 CT55 FAM161A GCC1 HGS KIFC3 MNS1 RNF6 ROPN1 SMARCD1 SUOX TCHP TEAD4 USHBP1 ZNF114 ZNF777	36 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STX11 TADA2A TCF4 TFIP11 TNS2 TRIM23 TRIM27 TRIM37 TSGA10 UBE2D1 UBE2H
Entrez ID		9851	6049
HPRD ID		11106	05027
Ensembl ID		ENSG00000198920	ENSG00000127870
Uniprot IDs		Q2KHM9	A0A024RDP2 A0A0S2Z4G9 Q9Y252
PDB IDs
Enriched GO Terms of Interacting Partners?
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