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MELK and PPP1R8
Data Source:
HPRD
(in vitro)
MELK
PPP1R8
Description
maternal embryonic leucine zipper kinase
protein phosphatase 1 regulatory subunit 8
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Cell Cortex
Membrane
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Nuclear Speck
Molecular Function
Protein Serine/threonine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Lipid Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
DNA Binding
RNA Binding
MRNA Binding
Endonuclease Activity
Protein Serine/threonine Phosphatase Inhibitor Activity
Protein Binding
Ribonuclease E Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Apoptotic Process
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Protein Autophosphorylation
Neural Precursor Cell Proliferation
MRNA Processing
RNA Catabolic Process
Cell Population Proliferation
RNA Splicing
Negative Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Protein Dephosphorylation
RNA Phosphodiester Bond Hydrolysis
Pathways
Drugs
Fostamatinib
Diseases
GWAS
Interacting Genes
11 interacting genes:
CDC25B
CDC5L
EIF2S1
EZH2
H1-5
LMNB1
MAPT
MBP
PPP1R8
SF3B1
ZNF622
27 interacting genes:
APP
APPBP2
CDC5L
CREBBP
CRMP1
CSNK2A1
CSNK2A2
CTNNBL1
EED
ERG28
FBXO25
GBP2
HDAC2
HMGA1
LRRK2
LYN
MELK
PPIL1
PPP1CA
PPP1CC
PRKACA
RBM48
RTN4IP1
SETDB1
SF3B1
STC2
WDR77
Entrez ID
9833
5511
HPRD ID
06119
04028
Ensembl ID
ENSG00000165304
ENSG00000117751
Uniprot IDs
B7Z1G6
Q14680
Q12972
Q6ICT4
PDB IDs
4BKY
4BKZ
4BL1
4D2P
4D2T
4D2V
4D2W
4IXP
4UMP
4UMQ
4UMR
4UMT
4UMU
5IH8
5IH9
5IHA
5IHC
5K00
5M5A
5MAF
5MAG
5MAH
5MAI
5TVT
5TWL
5TWU
5TWY
5TWZ
5TX3
6GVX
6VXR
3V4Y
Enriched GO Terms of Interacting Partners
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