MELK and H1-5

Data Source:
HPRD (in vitro)

		MELK	H1-5
Description		maternal embryonic leucine zipper kinase	H1.5 linker histone, cluster member
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Cortex Membrane	Chromatin Nucleosome Heterochromatin Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622	31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		9833	3009
HPRD ID		06119	00821
Ensembl ID		ENSG00000165304	ENSG00000184357
Uniprot IDs		B7Z1G6 Q14680	P16401
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR	2FE2 2RHI
Enriched GO Terms of Interacting Partners?
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