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GIT2 and PAK3
Data Source:
HPRD
(in vivo)
GIT2
PAK3
Description
GIT ArfGAP 2
p21 (RAC1) activated kinase 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Focal Adhesion
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Postsynaptic Density
Glutamatergic Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
Metal Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Small GTPase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of GTPase Activity
MAPK Cascade
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Axonogenesis
Positive Regulation Of Fibroblast Migration
Dendrite Development
Regulation Of Actin Filament Polymerization
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Regulation Of Axonogenesis
Synapse Organization
T Cell Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Organic Cyclic Compound
Positive Regulation Of DNA Biosynthetic Process
Pathways
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Drugs
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
GWAS
Bipolar disorder (
31043756
)
Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia (
28922980
)
Metabolic syndrome (
20694148
)
Metabolite levels (
23823483
)
Metabolite levels (MHPG) (
23319000
)
Interacting Genes
48 interacting genes:
ACTG1
ACTN1
ARHGEF6
ARHGEF7
ATF5
C4BPA
CALCOCO2
CDC42
CORO1A
E2F2
EDC4
GCH1
GET4
GIT1
GRK2
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LAMTOR5
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
13 interacting genes:
ARHGEF6
ARHGEF7
CDC42
GIT1
GIT2
MYO6
NCK1
PXN
RAC1
RAF1
RHOJ
SNCA
SYN1
Entrez ID
9815
5063
HPRD ID
09779
02142
Ensembl ID
ENSG00000139436
ENSG00000077264
Uniprot IDs
F8VXI9
F8W822
Q14161
Q68DM7
Q6FI58
B2RCU6
O75914
PDB IDs
6FD3
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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