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PAK3 and MYO6
Data Source:
HPRD
(in vitro, in vivo)
PAK3
MYO6
Description
p21 (RAC1) activated kinase 3
myosin VI
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Postsynaptic Density
Glutamatergic Synapse
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Clathrin-coated Pit
Cell Cortex
Actin Cytoskeleton
Membrane
Unconventional Myosin Complex
RNA Polymerase II, Holoenzyme
Endocytic Vesicle
Filopodium
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Filamentous Actin
Nuclear Membrane
Vesicle
Ruffle Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Small GTPase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Microfilament Motor Activity
Motor Activity
Actin Binding
Protein Binding
Calmodulin Binding
ATP Binding
Actin-dependent ATPase Activity
ADP Binding
Actin Filament Binding
Minus-end Directed Microfilament Motor Activity
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Axonogenesis
Positive Regulation Of Fibroblast Migration
Dendrite Development
Regulation Of Actin Filament Polymerization
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Regulation Of Axonogenesis
Synapse Organization
T Cell Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Organic Cyclic Compound
Positive Regulation Of DNA Biosynthetic Process
Intracellular Protein Transport
Endocytosis
Actin Filament Organization
Sensory Perception Of Sound
Actin Filament-based Movement
Vesicle Transport Along Actin Filament
DNA Damage Response, Signal Transduction By P53 Class Mediator
Inner Ear Morphogenesis
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Secretion
Pathways
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gap junction degradation
Trafficking of AMPA receptors
Drugs
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
Deafness, autosomal dominant
Deafness, autosomal recessive
GWAS
Prostate cancer (
25217961
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
13 interacting genes:
ARHGEF6
ARHGEF7
CDC42
GIT1
GIT2
MYO6
NCK1
PXN
RAC1
RAF1
RHOJ
SNCA
SYN1
20 interacting genes:
ACTA1
APC
CALCOCO2
CALM2
CDC42
CDH1
CLTB
DAB1
DAB2
DLG1
GIPC1
LRCH3
OPTN
PAK1
PAK3
RNF11
TOM1
TOM1L2
UBC
WBP2
Entrez ID
5063
4646
HPRD ID
02142
02985
Ensembl ID
ENSG00000077264
ENSG00000196586
Uniprot IDs
B2RCU6
O75914
Q9UM54
PDB IDs
6FD3
2N0Z
2N10
2N11
2N12
2N13
6E5N
6J56
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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