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PAK3 and NCK1
Data Source:
HPRD
(in vitro)
PAK3
NCK1
Description
p21 (RAC1) activated kinase 3
NCK adaptor protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Postsynaptic Density
Glutamatergic Synapse
Protein Phosphatase Type 1 Complex
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Small GTPase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Kinase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Cytoskeletal Anchor Activity
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Cadherin Binding
Ephrin Receptor Binding
Eukaryotic Initiation Factor EIF2 Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Axonogenesis
Positive Regulation Of Fibroblast Migration
Dendrite Development
Regulation Of Actin Filament Polymerization
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Regulation Of Axonogenesis
Synapse Organization
T Cell Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Organic Cyclic Compound
Positive Regulation Of DNA Biosynthetic Process
Negative Regulation Of Protein Kinase Activity
Substrate-dependent Cell Migration, Cell Extension
Actin Filament Organization
Signal Complex Assembly
Positive Regulation Of Neuron Projection Development
Lamellipodium Assembly
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Response To Other Organism
Negative Regulation Of Cell Death
Peptidyl-serine Dephosphorylation
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cap-dependent Translational Initiation
Positive Regulation Of Cap-independent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Downstream signal transduction
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
Nephrin family interactions
DCC mediated attractive signaling
DCC mediated attractive signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Blood urea nitrogen levels (
31152163
)
Body mass index (
25673413
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
13 interacting genes:
ARHGEF6
ARHGEF7
CDC42
GIT1
GIT2
MYO6
NCK1
PXN
RAC1
RAF1
RHOJ
SNCA
SYN1
95 interacting genes:
ABI1
ABI2
ABL1
ADAM15
ADGRL2
ARHGAP32
ARHGEF7
BCAR1
BLNK
BRK1
CAV2
CBL
CBLB
CD3E
CHN2
CRK
CSNK1G2
CYFIP2
DAG1
DCC
DLGAP4
DNM1
DOK1
DOK2
DRD3
DRD4
EFS
EGFR
EIF2B2
EIF2S2
EPHB1
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FCHO1
FGFR1
FLT1
FLT3
FRS2
GAB1
GAB2
GMPPA
HOMEZ
KDR
KHDRBS1
KIAA1522
KIT
LCP2
MAP4K1
MAP4K4
MET
MINK1
NCKAP1
NCKAP5
NCKIPSD
NEDD9
NHSL2
NPHS1
NTRK2
NUTM2F
OLIG1
PAK1
PAK2
PAK3
PDGFRB
PFN1
PHC2
PIK3AP1
PIK3R3
PKN2
PLCG1
PTK2
PXN
RAC1
RASA1
RHOU
RRAS
SH2D1A
SHANK3
SOCS1
SOCS7
SORBS3
SOS1
SYNJ2
SYNPO
TBK1
TNIK
TNK2
UBA52
WAS
WASF1
WASL
WIPF1
Entrez ID
5063
4690
HPRD ID
02142
02740
Ensembl ID
ENSG00000077264
ENSG00000158092
Uniprot IDs
B2RCU6
O75914
A0A0S2Z4Y3
P16333
PDB IDs
6FD3
2CI8
2CI9
2CUB
2JS0
2JS2
2JW4
5QU1
5QU2
5QU3
5QU4
5QU5
5QU6
5QU7
5QU8
5QUA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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