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IKBKE and BIRC3
Data Source:
BioGRID
(enzymatic study)
IKBKE
BIRC3
Description
inhibitor of nuclear factor kappa B kinase subunit epsilon
baculoviral IAP repeat containing 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
PML Body
Mitochondrial Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Phosphorylation
Immune Response
I-kappaB Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lipid Storage
Viral Process
Peptidyl-serine Phosphorylation
Negative Regulation Of Type I Interferon Production
Response To Type I Interferon
Response To Interferon-beta
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Virus
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Ubiquitination
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of RIG-I Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity
Pathways
SUMOylation of immune response proteins
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Fostamatinib
Diseases
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
27399966
)
Prostate cancer (
23535732
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
22 interacting genes:
AZI2
BIRC2
BIRC3
CDC37
CHUK
CYLD
DDX3X
FKBP5
HSP90AA1
HSP90AB1
IRF3
IRF5
KTN1
MBP
NFKBIA
RELA
RIPK1
SIKE1
TANK
TICAM1
TRIM27
XIAP
41 interacting genes:
BCL10
BIRC5
CASP3
CASP7
CASP9
CD40
CYFIP2
DIABLO
DZIP3
GLMN
GSPT1
HAX1
HTRA2
IKBKE
IKBKG
MAP3K14
MBTPS1
PACS2
PELI1
RAF1
RCHY1
RIPK1
RIPK2
RIPK3
RIPK4
SNX7
SPHK1
SUMO1
TRAF1
TRAF2
TRAF3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2N
UBE2Q2
UBE2V1
USP19
YOD1
Entrez ID
9641
330
HPRD ID
05442
03426
Ensembl ID
ENSG00000263528
ENSG00000023445
Uniprot IDs
A0A075B7B4
Q14164
Q13489
PDB IDs
2UVL
3EB5
3EB6
3M0A
3M0D
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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