BIRC3 and RIPK4

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		BIRC3	RIPK4
Description		baculoviral IAP repeat containing 3	receptor interacting serine/threonine kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity	Morphogenesis Of An Epithelium Protein Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		41 interacting genes: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1	10 interacting genes: BIRC2 BIRC3 GPSM3 PRKCB PRKCD RHOA SPAG8 TRAF7 VWC2L XIAP
Entrez ID		330	54101
HPRD ID		03426	10419
Ensembl ID		ENSG00000023445	ENSG00000183421
Uniprot IDs		Q13489	Q96T11 Q9H4D1
PDB IDs		2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?
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