BIRC3 and PACS2

Data Source:
BioGRID (pull down)

		BIRC3	PACS2
Description		baculoviral IAP repeat containing 3	phosphofurin acidic cluster sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Mitochondrion Endoplasmic Reticulum
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ion Channel Binding
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity	Autophagosome Assembly Apoptotic Process Viral Process Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization To Phagophore Assembly Site Protein Localization To Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		41 interacting genes: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1	4 interacting genes: BIRC2 BIRC3 PKD2 TRAF2
Entrez ID		330	23241
HPRD ID		03426	17816
Ensembl ID		ENSG00000023445	ENSG00000179364
Uniprot IDs		Q13489	Q86VP3 Q8N7J0
PDB IDs		2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?
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