TCL1B and MARK1

Data Source:
BioGRID (two hybrid)

		TCL1B	MARK1
Description		TCL1 family AKT coactivator B	microtubule affinity regulating kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Protein-containing Complex	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Refractive error ( 32231278)	Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes		17 interacting genes: AKT1 AKT2 APP BAG4 EFCAB2 GLRX3 LSM1 LSM5 LSM7 MARK1 MEIS3 MKRN3 PLEKHA3 PNMA1 SNRPG TNPO2 ZNF330	10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2
Entrez ID		9623	4139
HPRD ID		04795	07353
Ensembl ID		ENSG00000213231	ENSG00000116141
Uniprot IDs		A0A024R6P4 O95988	A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4
PDB IDs			2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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