MARK1 and TAOK1

Data Source:
HPRD (in vitro)

		MARK1	TAOK1
Description		microtubule affinity regulating kinase 1	TAO kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite	Cytoplasm Cytosol Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Beta-tubulin Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization	MAPK Cascade Activation Of MAPK Activity Microtubule Cytoskeleton Organization DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Mitotic G2 DNA Damage Checkpoint Activation Of JUN Kinase Activity Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Cytoskeleton Organization Neuron Cellular Homeostasis Regulation Of Microtubule Cytoskeleton Organization Execution Phase Of Apoptosis Positive Regulation Of Protein Acetylation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Mean platelet volume ( 22139419 24026423 19110211 19820697 32888494 22423221 27863252) Platelet count ( 22139419 29066854 32888494) Red cell distribution width ( 32888494)
Interacting Genes		10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2	7 interacting genes: C8orf33 CSNK1E DYNC1I1 GEMIN7 MAP2K3 MARK1 WT1
Entrez ID		4139	57551
HPRD ID		07353	15467
Ensembl ID		ENSG00000116141	ENSG00000160551
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	A0A024QZ70 Q7L7X3
PDB IDs		2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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