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CLOCK and PER2
Data Source:
BioGRID
(two hybrid)
CLOCK
PER2
Description
clock circadian regulator
period circadian regulator 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytosol
Chromatoid Body
Intracellular Membrane-bounded Organelle
CLOCK-BMAL Transcription Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Histone Acetyltransferase Activity
Protein Binding
Chromatin DNA Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
Transcription Coactivator Activity
Protein Binding
Biological Process
DNA Damage Checkpoint
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Acetylation
Signal Transduction
Spermatogenesis
Circadian Rhythm
Photoperiodism
Histone Acetylation
Circadian Regulation Of Gene Expression
Regulation Of Hair Cycle
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Regulation Of Insulin Secretion
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Redox State
Cellular Response To Ionizing Radiation
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Response To Ischemia
Glycogen Biosynthetic Process
Gluconeogenesis
Fatty Acid Metabolic Process
Circadian Rhythm
Regulation Of Vasoconstriction
Lactate Biosynthetic Process
Negative Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Neurogenesis
Regulation Of Insulin Secretion
White Fat Cell Differentiation
Regulation Of Cell Cycle
Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
Negative Regulation Of Fat Cell Proliferation
Histone H3 Deacetylation
Circadian Regulation Of Translation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
BMAL1:CLOCK,NPAS2 activates circadian gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
HATs acetylate histones
Circadian Clock
Circadian Clock
Drugs
Diseases
Familial advanced sleep phase syndrome
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
33020668
)
Cortical surface area (MOSTest) (
32665545
)
Height (
25282103
)
Neutrophil percentage of white cells (
32888494
)
Personality dimensions (
18957941
)
Subcortical volume (MOSTest) (
32665545
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Chronotype (
26955885
30696823
27494321
)
Morning vs. evening chronotype (
26955885
26835600
27494321
)
Interacting Genes
26 interacting genes:
ARNTL
ARNTL2
BHLHE41
CRY1
CRY2
CSNK1E
CSNK2B
DBP
DELEC1
EP300
KAT2B
NPAS2
PER2
PER3
PPP1CA
PPP1CB
PPP1CC
PPP2R1B
PPP2R5D
PPP2R5E
RARA
RHOA
RORB
RORC
RXRA
SIRT1
25 interacting genes:
BHLHE41
BTRC
CLOCK
CRY1
CRY2
CSNK1D
CSNK1E
CSNK2B
DELEC1
ELOA
LENG8
LMO4
MDM2
MLH1
PER1
PER3
RORC
TIMELESS
TP53
TPT1
TPTEP2-CSNK1E
UBE2D1
UBE2D2
UBE2D3
UBL4A
Entrez ID
9575
8864
HPRD ID
03508
04575
Ensembl ID
ENSG00000134852
ENSG00000132326
Uniprot IDs
O15516
Q3ZCT4
Q53EU0
O15055
PDB IDs
4H10
6QPJ
6OF7
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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