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PER2 and BHLHE41
Data Source:
BioGRID
(two hybrid)
PER2
BHLHE41
Description
period circadian regulator 2
basic helix-loop-helix family member e41
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
Transcription Coactivator Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
MRF Binding
Protein Heterodimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Ischemia
Glycogen Biosynthetic Process
Gluconeogenesis
Fatty Acid Metabolic Process
Circadian Rhythm
Regulation Of Vasoconstriction
Lactate Biosynthetic Process
Negative Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Neurogenesis
Regulation Of Insulin Secretion
White Fat Cell Differentiation
Regulation Of Cell Cycle
Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
Negative Regulation Of Fat Cell Proliferation
Histone H3 Deacetylation
Circadian Regulation Of Translation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Negative Regulation Of Myotube Differentiation
Negative Regulation Of Transcription By Competitive Promoter Binding
Circadian Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Regulation Of Neurogenesis
Pathways
Circadian Clock
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Drugs
Diseases
Familial advanced sleep phase syndrome
GWAS
Chronotype (
26955885
30696823
27494321
)
Morning vs. evening chronotype (
26955885
26835600
27494321
)
Response to bupropion and depression (
27622933
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
25 interacting genes:
BHLHE41
BTRC
CLOCK
CRY1
CRY2
CSNK1D
CSNK1E
CSNK2B
DELEC1
ELOA
LENG8
LMO4
MDM2
MLH1
PER1
PER3
RORC
TIMELESS
TP53
TPT1
TPTEP2-CSNK1E
UBE2D1
UBE2D2
UBE2D3
UBL4A
22 interacting genes:
BHLHE40
CLOCK
CRY1
CRY2
CSNK1E
CSNK2A1
CSNK2A2
CSNK2B
DELEC1
FBXW11
GSK3B
MYOD1
NONO
PER2
PPP2CB
PPP2R1B
PPP2R5E
RASD1
RORA
RORC
SIRT1
WDR5
Entrez ID
8864
79365
HPRD ID
04575
16204
Ensembl ID
ENSG00000132326
ENSG00000123095
Uniprot IDs
O15055
A0A024RAV8
Q8TAT1
Q9C0J9
PDB IDs
6OF7
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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