AIM2 and RNF4

Data Source:
BioGRID (two hybrid)

		AIM2	RNF4
Description		absent in melanoma 2	ring finger protein 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol AIM2 Inflammasome Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End
	Molecular Function	Double-stranded DNA Binding Protein Binding Identical Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta Cellular Response To Drug NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Pyroptosis Pyroptosome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways		The AIM2 inflammasome The AIM2 inflammasome	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)	Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: ANP32B APPBP2 RNF4	133 interacting genes: ACTB AIM2 AKAP17A AR ARID3C ATF2 ATXN1 BCL2L1 BTBD1 BTBD3 C14orf119 C18orf25 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPC HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PATZ1 PCBP3 PGR PHC1 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2
Entrez ID		9447	6047
HPRD ID		05202	04167
Ensembl ID		ENSG00000163568	ENSG00000063978
Uniprot IDs		O14862	P78317
PDB IDs		3RN2 3RN5 3VD8 4O7Q 6MB2	2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?
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