RNF4 and PGR

Data Source:
BioGRID (two hybrid)

		RNF4	PGR
Description		ring finger protein 4	progesterone receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Chromatin Nucleoplasm Mitochondrial Outer Membrane Cytosol
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding ATPase Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Ovulation From Ovarian Follicle Epithelial Cell Maturation Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Negative Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Paracrine Signaling Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression
Drugs			Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Diastolic blood pressure ( 30224653) Length of menstrual cycle ( 30202859) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		133 interacting genes: ACTB AIM2 AKAP17A AR ARID3C ATF2 ATXN1 BCL2L1 BTBD1 BTBD3 C14orf119 C18orf25 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPC HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PATZ1 PCBP3 PGR PHC1 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	53 interacting genes: ANP32A APEX2 ARID1A BATF3 BCAS2 BMI1 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 DNAJA1 ESR1 FKBP5 HMGB1 HMGB2 HSPA1A JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SGTA SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17
Entrez ID		6047	5241
HPRD ID		04167	07077
Ensembl ID		ENSG00000063978	ENSG00000082175
Uniprot IDs		P78317	P06401
PDB IDs		2EA6 2XEU 4PPE	1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
Enriched GO Terms of Interacting Partners?
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