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RNF4 and IKBKG
Data Source:
BioGRID
(two hybrid)
RNF4
IKBKG
Description
ring finger protein 4
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
Microtubule End
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Nuclear Receptor Coactivator Activity
Nucleosome Binding
SUMO Polymer Binding
Identical Protein Binding
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Arsenic-containing Substance
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Regulation Of Spindle Assembly
Regulation Of Kinetochore Assembly
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Inflammatory Response
Immune Response
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Response To Virus
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Positive Regulation Of Macroautophagy
Protein Deubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Neuron Death
Pathways
Processing of DNA double-strand break ends
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
AGRO100
Tarenflurbil
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Incontinentia pigmenti
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS
Colorectal adenoma (advanced) (
29228715
)
Colorectal cancer (
29228715
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Dimensional psychopathology (Social) (
29496196
)
Tourette syndrome (
30818990
)
Hemoglobin levels (
26366553
)
Interacting Genes
133 interacting genes:
ACTB
AIM2
AKAP17A
AR
ARID3C
ATF2
ATXN1
BCL2L1
BTBD1
BTBD3
C14orf119
C18orf25
CAMK2B
CAMK2D
CCL2
CFL2
CREB1
DAXX
DDX39A
DDX39B
DES
DESI1
EHHADH
ESR1
ESRRA
FADD
FAM118A
FAM9A
FKBP6
GMCL1
GSC2
H3C14
HGS
HMGA1
HNF4A
HNRNPC
HNRNPCL1
HNRNPCL2
HNRNPH1
HNRNPK
IKBKG
IKZF1
IMPDH1
KLHL12
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3B
LCE5A
LXN
MYD88
NKX3-1
NMNAT1
NTAQ1
NVL
PAICS
PATZ1
PCBP3
PGR
PHC1
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RHOXF2
RUNX1T1
SCML2
SEPTIN3
SKIL
SNAPC5
SOX5
SP1
SRPK2
SSNA1
STX1A
STX2
STX4
SUMO1
SUMO2
TBP
TCF20
TERF2
TFG
THAP1
TRAF2
TRAF3
TRAF4
TRAF5
TRAIP
TRIM28
TRIM38
TRIM54
TRIP13
TRPS1
UBC
UBE2A
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2T
UBE2W
UBQLN1
UBQLN2
UBTD2
UEVLD
VENTX
ZBTB26
ZBTB34
ZBTB6
ZC3H10
ZCCHC17
ZFP42
ZNF275
ZNF319
ZNF696
ZNF792
ZNRD2
242 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BIRC3
BRME1
C19orf12
CALB1
CALCOCO2
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IFIT5
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAP3K7
MAPRE1
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RELA
RET
RHOA
RIPK1
RIPK2
RNF11
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP10
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
Entrez ID
6047
8517
HPRD ID
04167
02217
Ensembl ID
ENSG00000063978
ENSG00000269335
Uniprot IDs
P78317
A0A087X1B1
Q9Y6K9
PDB IDs
2EA6
2XEU
4PPE
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
Enriched GO Terms of Interacting Partners
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