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CD86 and CD28
Data Source:
HPRD
(in vivo)
CD86
CD28
Description
CD86 molecule
CD28 molecule
Image
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Centriolar Satellite
Extracellular Exosome
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Molecular Function
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Signaling Receptor Activity
Protease Binding
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Biological Process
Adaptive Immune Response
Immunoglobulin Production
Immune Response
Cell Surface Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
CD40 Signaling Pathway
T Cell Costimulation
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of T Cell Proliferation
B Cell Activation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Viral Entry Into Host Cell
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Lipopolysaccharide
Positive Regulation Of NIK/NF-kappaB Signaling
Activation Of Protein Kinase C Activity
Cytokine Production
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Pathways
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Antithymocyte immunoglobulin (rabbit)
Abatacept
Belatacept
Bryostatin 1
Diseases
GWAS
Autoimmune thyroid disease (
32581359
)
Diffuse large B cell lymphoma (
25261932
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Follicular lymphoma (
25279986
)
Gut microbiota (functional units) (
27694959
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
27386562
)
Selective IgA deficiency (
27723758
)
Systemic lupus erythematosus (
19838195
)
Type 2 diabetes (
30718926
)
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Interacting Genes
6 interacting genes:
CD28
CD80
CTLA4
ECE2
MARCHF8
PARP1
17 interacting genes:
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
Entrez ID
942
940
HPRD ID
03011
01727
Ensembl ID
ENSG00000114013
ENSG00000178562
Uniprot IDs
A0A0X9R4E0
A8K632
P42081
B4E0L1
P10747
PDB IDs
1I85
1NCN
5YXK
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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