CD86 and ECE2

Data Source:
BioGRID (two hybrid)

		CD86	ECE2
Description		CD86 molecule	endothelin converting enzyme 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome	Golgi Membrane Plasma Membrane Integral Component Of Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity	Cell-cell Signaling Protein Processing Peptide Hormone Processing Methylation
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Peptide ligand-binding receptors
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)	Body mass index ( 29273807) Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1	6 interacting genes: CASP10 CD53 CD86 MTNR1A SYNE4 UBC
Entrez ID		942	9718
HPRD ID		03011	09931
Ensembl ID		ENSG00000114013	ENSG00000145194
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	P0DPD6 P0DPD8
PDB IDs		1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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