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CD28 and IL12A
Data Source:
HPRD
(in vivo, in vitro)
CD28
IL12A
Description
CD28 molecule
interleukin 12A
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Late Endosome Lumen
Interleukin-12 Complex
Molecular Function
Protease Binding
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Cytokine Activity
Interleukin-12 Receptor Binding
Protein Binding
Growth Factor Activity
Interleukin-12 Beta Subunit Binding
Interleukin-27 Binding
Protein Heterodimerization Activity
Biological Process
Cytokine Production
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Immune Response
Cell Cycle Arrest
Response To Virus
Response To UV-B
Viral Process
Cell Migration
Cytokine-mediated Signaling Pathway
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Natural Killer Cell Activation
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Interleukin-12-mediated Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Negative Regulation Of Protein Secretion
Defense Response To Gram-positive Bacterium
Positive Regulation Of NK T Cell Activation
Interleukin-35-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Dendritic Cell Chemotaxis
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-12 signaling
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Autoimmune traits (pleiotropy) (
30572963
)
Behcet's disease (
23291587
27548383
25799145
)
Bipolar disorder (
31043756
)
Celiac disease (
22057235
20190752
25920553
18311140
)
Limited cutaneous systemic scleroderma (
24387989
)
Major depressive disorder (
23377640
)
Multiple sclerosis (
24076602
19525953
21833088
)
Primary biliary cholangitis (
28425483
19458352
21399635
20639880
26394269
28062665
)
Primary biliary cirrhosis (
22961000
)
Sjögren's syndrome (
24097067
)
Systemic lupus erythematosus (
27399966
26502338
28714469
)
Systemic sclerosis (
24387989
31672989
)
Interacting Genes
17 interacting genes:
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
5 interacting genes:
CD28
CXCL8
EBI3
IL12B
WASF1
Entrez ID
940
3592
HPRD ID
01727
01193
Ensembl ID
ENSG00000178562
ENSG00000168811
Uniprot IDs
B4E0L1
P10747
O60595
P29459
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
1F45
3HMX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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