SH2B3 and ERBB2

Data Source:
BioGRID (pull down, unspecified method)

		SH2B3	ERBB2
Description		SH2B adaptor protein 3	erb-b2 receptor tyrosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane ERBB3:ERBB2 Complex Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Stem Cell Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein Tyrosine Kinase Binding	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Neutrophil Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Negative Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Intracellular Signal Transduction Monocyte Homeostasis Megakaryocyte Development Cellular Response To Interleukin-3 Thrombopoietin-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Erythrocyte Development Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Negative Regulation Of Kit Signaling Pathway Cellular Response To Chemokine	MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Intracellular Signal Transduction ERBB2 Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Motility
Pathways		Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production	Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Pazopanib	Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib
Diseases		Type I diabetes mellitus	Choriocarcinoma Pancreatic cancer Gastric cancer Bladder cancer Endometrial Cancer Ovarian cancer Cholangiocarcinoma Breast cancer Cervical cancer
GWAS		Allergic rhinitis ( 30013184) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 29273807) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430479 19430483 27841878 21909115 28739976 27618447 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 19198610 32888494) Fibrinogen levels ( 28107422 26561523) Gastroesophageal reflux disease ( 31527586) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) IgA levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 31959993) Ischemic stroke ( 24262325 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Left ventricular end-diastolic volume ( 32382064) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 28017375) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 26343387) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 22139419 24026423 32888494 25705162 20139978 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763 27992413) Reaction time ( 27046643) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342 20453842) Sarcoidosis ( 26051272) Small vessel stroke (CCS or TOAST classification) ( 32047268) Small vessel stroke (CCSp classification) ( 32047268) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 27182965 28928442) Tumor necrosis factor levels ( 32805626) Type 1 diabetes ( 21829393 25751624 19430480 17554300 30572963) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 32499647) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)	Adult asthma ( 30787307) Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)
Interacting Genes		12 interacting genes: CD247 EGFR ERBB2 ERBB3 ERBB4 FLNA GRB2 KIT LCK MET TNS2 ZAP70	350 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 APLP1 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCND2 CCT3 CD44 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHB1 EPHB2 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR INSRR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYN LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532
Entrez ID		10019	2064
HPRD ID		05480	01281
Ensembl ID		ENSG00000111252	ENSG00000141736
Uniprot IDs		B7Z7K6 F5GYM4 Q59H48 Q96BA5 Q9UQQ2	F5H1T4 J3QLU9 P04626 X5DNK3
PDB IDs			1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6OGE
Enriched GO Terms of Interacting Partners?
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