SESTD1 and RABGEF1

Data Source:
BioGRID (two hybrid)

		SESTD1	RABGEF1
Description		SEC14 and spectrin domain containing 1	RAB guanine nucleotide exchange factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Calcium Channel Complex Intermediate Filament Cytoskeleton	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	Phosphatidylserine Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylcholine Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity
Pathways			TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Late-onset Alzheimer's disease ( 27770636) Objective response to lithium treatment ( 26503763) Optic disc size ( 31809533) Presence of antiphospholipid antibodies ( 23509613) Refractive error ( 32231278) Serum uric acid levels ( 29559957)	Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)
Interacting Genes		10 interacting genes: CBX8 DACT3 GPS2 HSF4 IQCB1 RABGEF1 STMN1 STMN2 TEAD4 ZNF830	50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C
Entrez ID		91404	27342
HPRD ID		11549	11477
Ensembl ID		ENSG00000187231	ENSG00000154710
Uniprot IDs		B3KTX3 Q86VW0	A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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