RABGEF1 and AP1G1

Data Source:
HPRD (two hybrid)

		RABGEF1	AP1G1
Description		RAB guanine nucleotide exchange factor 1	adaptor related protein complex 1 subunit gamma 1
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GO Annotations	Cellular Component	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding	Protein Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity Cargo Adaptor Activity
	Biological Process	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity	Intracellular Protein Transport Golgi To Vacuole Transport Receptor-mediated Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Golgi To Lysosome Transport
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)	General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	27 interacting genes: AAGAB AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 HEATR5B KIF13A MAP1A PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		27342	164
HPRD ID		11477	04637
Ensembl ID		ENSG00000154710	ENSG00000166747
Uniprot IDs		A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41	A0A140VJE7 O43747 Q8IY97
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	1IU1
Enriched GO Terms of Interacting Partners?
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