TIMELESS and PER2

Data Source:
HPRD (in vitro)

		TIMELESS	PER2
Description		timeless circadian regulator	period circadian regulator 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding
	Biological Process	DNA Replication Checkpoint Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of An Epithelium DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Processing of DNA double-strand break ends	Circadian Clock
Drugs
Diseases			Familial advanced sleep phase syndrome
GWAS		Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)
Interacting Genes		9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1	25 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MDM2 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBE2D1 UBE2D2 UBE2D3 UBL4A
Entrez ID		8914	8864
HPRD ID		04864	04575
Ensembl ID		ENSG00000111602	ENSG00000132326
Uniprot IDs		Q9UNS1	O15055
PDB IDs		4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ	6OF7
Enriched GO Terms of Interacting Partners?
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