CCN4 and DCN

Data Source:
HPRD (in vitro)

		CCN4	DCN
Description		cellular communication network factor 4	decorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Extracellular Matrix	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding
	Biological Process	Osteoblast Differentiation Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Smooth Muscle Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Osteoclast Differentiation Negative Regulation Of Chondrocyte Differentiation Glucose Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Bone Development Negative Regulation Of Cell Death Positive Regulation Of Wound Healing	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways			Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases			Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS			Blood protein levels ( 30072576) Central corneal thickness ( 32528159 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)
Interacting Genes		4 interacting genes: BGN DCN HOXA1 OTX1	30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF
Entrez ID		8840	1634
HPRD ID		16019	00501
Ensembl ID		ENSG00000104415	ENSG00000011465
Uniprot IDs		O95388	A0A024RBG6 P07585 Q6FH10
PDB IDs
Enriched GO Terms of Interacting Partners?
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