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DCN and DPT
Data Source:
HPRD
(in vitro)
DCN
DPT
Description
decorin
dermatopontin
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Type VI Trimer
Extracellular Space
Golgi Lumen
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Extracellular Space
Collagen-containing Extracellular Matrix
Molecular Function
RNA Binding
Protein Binding
Collagen Binding
Glycosaminoglycan Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Protein N-terminus Binding
Extracellular Matrix Binding
Extracellular Matrix Structural Constituent
Protein Binding
Biological Process
Kidney Development
Placenta Development
Skeletal Muscle Tissue Development
Aging
Response To Mechanical Stimulus
Animal Organ Morphogenesis
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Negative Regulation Of Angiogenesis
Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan
Extracellular Matrix Organization
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Response To Lipopolysaccharide
Wound Healing
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Collagen Fibril Organization
Pathways
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS
Blood protein levels (
30072576
)
Central corneal thickness (
32528159
29760442
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Sudden cardiac arrest (
21658281
)
Blood protein levels (
30072576
29875488
28240269
)
Diisocyanate-induced asthma (
25918132
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
)
Morbidity-free survival (
17903295
)
PR interval (
32439900
)
Rosacea symptom severity (
29771307
)
Interacting Genes
30 interacting genes:
AHSG
BRCA1
C1QA
CCN4
COL14A1
COL1A1
COL1A2
COL4A1
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
DPT
EGFR
ELN
FBN1
FLNA
FN1
MET
MMP2
MMP3
MMP7
PLA2G2A
SFTPD
TGFB1
TGFB2
THBS1
TNF
4 interacting genes:
BAG6
DCN
LOX
TGFB1
Entrez ID
1634
1805
HPRD ID
00501
00510
Ensembl ID
ENSG00000011465
ENSG00000143196
Uniprot IDs
A0A024RBG6
P07585
Q6FH10
Q07507
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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