Wiki-Pi
About
Search
Browse
People
Updates
Search
DCN and MMP2
Data Source:
HPRD
(in vitro)
DCN
MMP2
Description
decorin
matrix metallopeptidase 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Type VI Trimer
Extracellular Space
Golgi Lumen
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Extracellular Region
Extracellular Space
Nucleus
Mitochondrion
Plasma Membrane
Sarcomere
Collagen-containing Extracellular Matrix
Molecular Function
RNA Binding
Protein Binding
Collagen Binding
Glycosaminoglycan Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Protein N-terminus Binding
Extracellular Matrix Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Metallopeptidase Activity
Zinc Ion Binding
Biological Process
Kidney Development
Placenta Development
Skeletal Muscle Tissue Development
Aging
Response To Mechanical Stimulus
Animal Organ Morphogenesis
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Negative Regulation Of Angiogenesis
Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan
Extracellular Matrix Organization
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Response To Lipopolysaccharide
Wound Healing
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Angiogenesis
Response To Hypoxia
Blood Vessel Maturation
Intramembranous Ossification
Proteolysis
Embryo Implantation
Cytokine-mediated Signaling Pathway
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Cellular Response To Reactive Oxygen Species
Endodermal Cell Differentiation
Cellular Protein Metabolic Process
Ephrin Receptor Signaling Pathway
Tissue Remodeling
Face Morphogenesis
Bone Trabecula Formation
Cellular Response To Amino Acid Stimulus
Cellular Response To UV-A
Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells
Interleukin-4 and Interleukin-13 signaling
Extra-nuclear estrogen signaling
Drugs
Marimastat
Captopril
SC-74020
Halofuginone
AE-941
Endostatin
Diseases
Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
Choriocarcinoma
Penile cancer
Torg-Winchester syndrome
GWAS
Blood protein levels (
30072576
)
Central corneal thickness (
32528159
29760442
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Sudden cardiac arrest (
21658281
)
Heel bone mineral density (
30598549
)
Lack of premeditation (
30718321
)
Refractive error (
32231278
)
Interacting Genes
30 interacting genes:
AHSG
BRCA1
C1QA
CCN4
COL14A1
COL1A1
COL1A2
COL4A1
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
DPT
EGFR
ELN
FBN1
FLNA
FN1
MET
MMP2
MMP3
MMP7
PLA2G2A
SFTPD
TGFB1
TGFB2
THBS1
TNF
39 interacting genes:
A2M
ACAN
BACE1
BCAN
CAPN3
CCL7
CLDN1
COL18A1
COL1A1
COL6A3
COL7A1
CXCL12
DCN
EPHB2
FGFR1
HAPLN1
HSP90AA1
IGFBP3
IL1B
ITGAV
KISS1
LCN2
LGALS3
MMP14
MMP17
MMP25
MTDH
MTNR1A
MTNR1B
PZP
REL
SPOCK1
TGFB1
THBS1
THBS2
TIMP1
TIMP2
TIMP3
TIMP4
Entrez ID
1634
4313
HPRD ID
00501
00386
Ensembl ID
ENSG00000011465
ENSG00000087245
Uniprot IDs
A0A024RBG6
P07585
Q6FH10
A0A024R6R4
P08253
PDB IDs
1CK7
1CXW
1EAK
1GEN
1GXD
1HOV
1J7M
1KS0
1QIB
1RTG
3AYU
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?