LMO4 and LDB1

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		LMO4	LDB1
Description		LIM domain only 4	LIM domain binding 1
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GO Annotations	Cellular Component	Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Transcription Factor Binding Metal Ion Binding	RNA Polymerase II Activating Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association DNA-binding Transcription Factor Binding
	Biological Process	Neural Tube Closure Ventricular Septum Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Regulation Of Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Mesendoderm Development Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Breast cancer ( 27354352) Eosinophil counts ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)
Interacting Genes		130 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 C12orf40 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG PPP1R32 QRICH1 RBAK RBBP8 RBPMS RCN1 RNF8 ROPN1 RPS6KA6 RSPH6A SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675	32 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IDI2 IRAK3 ISL1 ISL2 LHX1 LHX2 LHX3 LHX4 LHX6 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP
Entrez ID		8543	8861
HPRD ID		09122	09144
Ensembl ID		ENSG00000143013	ENSG00000198728
Uniprot IDs		P61968	A0A6E1WJ75 Q86U70
PDB IDs		2L4Z	2XJY 2XJZ 2YPA 6TYD
Enriched GO Terms of Interacting Partners?
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