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LMO4 and EXOSC8
Data Source:
BioGRID
(two hybrid)
LMO4
EXOSC8
Description
LIM domain only 4
exosome component 8
Image
GO Annotations
Cellular Component
Transcription Regulator Complex
Cell Leading Edge
RNA Polymerase II Transcription Regulator Complex
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Transcription Factor Binding
Metal Ion Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Identical Protein Binding
Biological Process
Neural Tube Closure
Ventricular Septum Development
Ventral Spinal Cord Interneuron Differentiation
Spinal Cord Motor Neuron Differentiation
Spinal Cord Association Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Kinase Activity
Regulation Of Cell Fate Specification
Positive Regulation Of Transcription By RNA Polymerase II
Thymus Development
Regulation Of Cell Activation
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Biological_process
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Breast cancer (
27354352
)
Eosinophil counts (
29403010
)
Gait rhythm (
26219847
)
Glaucoma (primary open-angle) (
29891935
)
Photic sneeze reflex (
27182965
)
Prostate-specific antigen levels (
28139693
)
Response to TNF antagonist treatment (
18615156
)
Resting heart rate (
27798624
)
White blood cell count (basophil) (
29403010
)
White blood cell types (
21738478
)
Interacting Genes
130 interacting genes:
AARD
ABI2
ADAMTSL4
AMOT
AMOTL2
ARNT2
BANP
BBS2
BCAS2
BIRC7
BRCA1
C12orf40
CALCOCO2
CCDC102B
CCDC120
CEP170P1
COG6
CRNN
CRYBB2
CSNK2B
CTBP2
CYSRT1
DDB1
DEAF1
DES
ECM1
ERCC6L
EXOSC8
FAM228A
FHL3
GABPB1
GADD45A
GOLGA2
GOLGA6L9
GRHL2
GSK3B
HELT
HGS
HSF2BP
ID3
IKZF1
IKZF3
ITSN1
KANK2
KATNBL1
KIAA1958
KIF3B
KPNA1
KRT15
KRT31
KRT33B
KRT34
KRT38
KRT39
KRT40
KRT74
KRT75
KRT76
KRTAP11-1
KRTAP3-1
KYNU
L3MBTL3
LASP1
LDB1
LDB2
LMO2
LZTS1
MCCD1
MERTK
METTL27
MID2
MTA1
MTUS2
MYOD1
MYOZ3
N4BP3
NFKBID
NFYC
NHLH1
NME4
NONO
NRF1
PDE4DIP
PELO
PER2
PITPNB
PLK1
PPARG
PPP1R32
QRICH1
RBAK
RBBP8
RBPMS
RCN1
RNF8
ROPN1
RPS6KA6
RSPH6A
SEC24D
SLC15A2
SMAD4
SMAD9
STAT5B
SUOX
TCF21
TCF4
TEX14
TFIP11
TINAGL1
TLE5
TNFSF11
TP53BP2
TRAF5
TRIM27
TRIM54
TSEN15
TTLL7
UBQLN2
VMAC
VPS52
WASHC1
ZBTB43
ZMYND12
ZNF135
ZNF202
ZNF213
ZNF397
ZNF410
ZNF467
ZNF675
74 interacting genes:
AEN
ATF2
C22orf39
CCDC28A-AS1
CNNM3
COL23A1
COX5A
CRMP1
CWC22
DDIT4L
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM161B
FAM90A1
FHOD1
FOXD4L1
FOXN3
FRG1
GEM
HAPLN2
HOXB9
INCA1
KANK2
KCNJ11
LMO4
LNX1
LSM1
LSM4
LSM7
MACIR
MKRN1
MORN4
MPHOSPH6
MTREX
MYOZ1
NEDD9
NTAQ1
OTUD4
PALS2
PHF21A
PIAS2
POLDIP3
RASD1
RASSF1
REL
RFC5
RPP14
RUSC1
RXRB
SLAIN1
SNAI1
SNRPB
SNRPC
SOCS7
SPATC1L
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP2
USP6
XRN1
XRN2
ZFP36
Entrez ID
8543
11340
HPRD ID
09122
09351
Ensembl ID
ENSG00000143013
ENSG00000120699
Uniprot IDs
P61968
Q96B26
PDB IDs
2L4Z
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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