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TRIM55 and CTNNB1
Data Source:
BioGRID
(two hybrid)
TRIM55
CTNNB1
Description
tripartite motif containing 55
catenin beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Microtubule
Euchromatin
Spindle Pole
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Cell Junction
Beta-catenin Destruction Complex
Protein-containing Complex
Protein-DNA Complex
Cell Projection
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Beta-catenin-TCF Complex
Wnt Signalosome
Molecular Function
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Enzyme Binding
Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Nuclear Hormone Receptor Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
I-SMAD Binding
Biological Process
Leukocyte Migration Involved In Inflammatory Response
Signal Transduction
Protein Ubiquitination
Diapedesis
Macrophage Migration
Protein Polyubiquitination
Branching Involved In Blood Vessel Morphogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Neuroblast Proliferation
Cell Adhesion
Wnt Signaling Pathway, Calcium Modulating Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Viral Process
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Regulation Of Centriole-centriole Cohesion
Response To Estradiol
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Protein Sumoylation
Adherens Junction Assembly
Protein Localization To Cell Surface
Hair Cell Differentiation
Entry Of Bacterium Into Host Cell
Detection Of Muscle Stretch
Embryonic Skeletal Limb Joint Morphogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Regulation Of Fibroblast Proliferation
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Histone H3-K4 Methylation
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Endothelial Tube Morphogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Regulation Of Calcium Ion Import
Cell-cell Adhesion
Positive Regulation Of Core Promoter Binding
Beta-catenin-TCF Complex Assembly
Beta-catenin Destruction Complex Disassembly
Midbrain Dopaminergic Neuron Differentiation
Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Neuron Projection Extension
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of DNA-templated Transcription, Initiation
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Adherens junctions interactions
Binding of TCF/LEF:CTNNB1 to target gene promoters
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Myogenesis
Myogenesis
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
RHO GTPases activate IQGAPs
Transcriptional Regulation by VENTX
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX3 regulates WNT signaling
Drugs
Urea
Diseases
Gastric cancer
Colorectal cancer
Endometrial Cancer
Pilomatricoma; Epithelioma calcificans of Malherbe
Thyroid cancer
Hepatocellular carcinoma
GWAS
Coronary heart disease event reduction (statin therapy interaction) (
22666496
)
Metabolite levels (
23823483
)
Recurrent major depressive disorder (
29317602
)
Bone mineral density (hip) (
27311723
19801982
)
Bone mineral density (total hip) (
29883787
)
Colorectal cancer (
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Lumbar spine bone mineral density (
29499414
)
Refractive error (
32231278
)
Systolic blood pressure (
30224653
)
Interacting Genes
310 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AFM
AGO2
AKR1C8P
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
ARL6IP4
ATG4D
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BCAT1
BCHE
BRAP
BRD4
BRWD1
BTBD9
BYSL
C10orf88
C12orf4
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC130
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CTSF
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DCTN3
DECR2
DEF8
DEK
DES
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
EPS8L2
ESPL1
EZH2
FAM185A
FAM90A1
FANK1
FASTKD1
FHL2
FKBP6
FLNA
FLNB
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
GRB14
HID1
HIRA
HOXA1
HROB
HSPB1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIF13A
KIF1B
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAGE3
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MDM4
MIDN
MIIP
MKI67
MLH3
MLLT11
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC3
MYBPHL
MYC
MYCT1
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NR2C2
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF1
PCGF3
PCGF6
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLD1
POLR2E
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PYGM
RABEPK
RAD23A
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNF10
RNF114
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SET
SHFL
SLC6A13
SLFN12
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
STAM
SYMPK
SYNCRIP
TCAP
TCP10L
TEX19
THAP3
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNI1
TNNI2
TNNI3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM27
TRIM35
TRIM41
TRIM54
TRIM63
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2L3
UCHL3
UCHL5
UNKL
USP13
USP28
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YOD1
YPEL3
ZBTB14
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
187 interacting genes:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARFGEF1
ARHGAP32
ASH2L
AXIN1
AXIN2
BCL3
BCL6
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CDC27
CDC34
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK2
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBIN
ESR1
EZR
FBXW2
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GNA13
GRIK2
GRIN1
GRIN2D
GSK3B
H1-2
HIF1A
HNF1A
HUWE1
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAP3K2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKM
PKP2
PLK1
PPM1A
PRKCG
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RUVBL1
RUVBL2
RXRA
SALL1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SMURF1
SOX1
SOX17
SP1
SPN
SRC
STUB1
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TLE1
TRIM33
TRIM55
TRIM63
TRIP10
TRRAP
UBE2B
UBE2D1
UBE2R2
UBE2S
UBE3A
UHRF2
USP2
USP9X
ZFYVE9
ZIC3
Entrez ID
84675
1499
HPRD ID
05927
00286
Ensembl ID
ENSG00000147573
ENSG00000168036
Uniprot IDs
Q9BYV6
A0A024R2Q3
B4DGU4
P35222
PDB IDs
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
6M90
6M91
6M92
6M93
6M94
6O9B
6O9C
6WLX
6WNX
Enriched GO Terms of Interacting Partners
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