Wiki-Pi
About
Search
Browse
People
Updates
Search
CTNNB1 and NFKB1
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo)
CTNNB1
NFKB1
Description
catenin beta 1
nuclear factor kappa B subunit 1
Image
GO Annotations
Cellular Component
Euchromatin
Spindle Pole
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Cell Junction
Beta-catenin Destruction Complex
Protein-containing Complex
Protein-DNA Complex
Cell Projection
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Beta-catenin-TCF Complex
Wnt Signalosome
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Secretory Granule Lumen
Specific Granule Lumen
Molecular Function
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Enzyme Binding
Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Nuclear Hormone Receptor Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
I-SMAD Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Actinin Binding
Biological Process
Protein Polyubiquitination
Branching Involved In Blood Vessel Morphogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Neuroblast Proliferation
Cell Adhesion
Wnt Signaling Pathway, Calcium Modulating Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Viral Process
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Regulation Of Centriole-centriole Cohesion
Response To Estradiol
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Protein Sumoylation
Adherens Junction Assembly
Protein Localization To Cell Surface
Hair Cell Differentiation
Entry Of Bacterium Into Host Cell
Detection Of Muscle Stretch
Embryonic Skeletal Limb Joint Morphogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Regulation Of Fibroblast Proliferation
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Histone H3-K4 Methylation
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Endothelial Tube Morphogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Regulation Of Calcium Ion Import
Cell-cell Adhesion
Positive Regulation Of Core Promoter Binding
Beta-catenin-TCF Complex Assembly
Beta-catenin Destruction Complex Disassembly
Midbrain Dopaminergic Neuron Differentiation
Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Neuron Projection Extension
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Transcription By RNA Polymerase II
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Negative Regulation Of Vitamin D Biosynthetic Process
Membrane Protein Intracellular Domain Proteolysis
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cholesterol Transport
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Interleukin-12 Production
Response To Muscle Stretch
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To DsRNA
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Hyaluronan Biosynthetic Process
Cellular Response To Angiotensin
Positive Regulation Of MiRNA Metabolic Process
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Adherens junctions interactions
Binding of TCF/LEF:CTNNB1 to target gene promoters
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Myogenesis
Myogenesis
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
RHO GTPases activate IQGAPs
Transcriptional Regulation by VENTX
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX3 regulates WNT signaling
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
HCMV Early Events
Purinergic signaling in leishmaniasis infection
Drugs
Urea
Donepezil
Pseudoephedrine
Thalidomide
Pranlukast
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Triflusal
Glycyrrhizic acid
Fish oil
SC-236
Diseases
Gastric cancer
Colorectal cancer
Endometrial Cancer
Pilomatricoma; Epithelioma calcificans of Malherbe
Thyroid cancer
Hepatocellular carcinoma
GWAS
Bone mineral density (hip) (
27311723
19801982
)
Bone mineral density (total hip) (
29883787
)
Colorectal cancer (
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Lumbar spine bone mineral density (
29499414
)
Refractive error (
32231278
)
Systolic blood pressure (
30224653
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Basophil percentage of white cells (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Copper levels (
26025379
)
Creatinine levels (
29124443
)
Crohn's disease (
28067908
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Estimated glomerular filtration rate (
29124443
30604766
)
Glomerular filtration rate (creatinine) (
26831199
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Membranous nephropathy (
32231244
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
21833088
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
23000144
21399635
26394269
28062665
30643196
)
Primary biliary cirrhosis (
22961000
)
Primary sclerosing cholangitis (
27992413
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (treatment resistant) (
22479419
)
Serum total protein level (
29403010
)
Serum uric acid levels (
29124443
)
Sum eosinophil basophil counts (
27863252
)
Systemic sclerosis (
31672989
30247649
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
23128233
)
White blood cell count (
32888494
)
Interacting Genes
187 interacting genes:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARFGEF1
ARHGAP32
ASH2L
AXIN1
AXIN2
BCL3
BCL6
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CDC27
CDC34
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK2
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBIN
ESR1
EZR
FBXW2
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GNA13
GRIK2
GRIN1
GRIN2D
GSK3B
H1-2
HIF1A
HNF1A
HUWE1
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAP3K2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKM
PKP2
PLK1
PPM1A
PRKCG
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RUVBL1
RUVBL2
RXRA
SALL1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SMURF1
SOX1
SOX17
SP1
SPN
SRC
STUB1
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TLE1
TRIM33
TRIM55
TRIM63
TRIP10
TRRAP
UBE2B
UBE2D1
UBE2R2
UBE2S
UBE3A
UHRF2
USP2
USP9X
ZFYVE9
ZIC3
104 interacting genes:
ABCC2
APBB2
AR
ATF3
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
DNMT3L
E2F1
ECSIT
ELF1
ELF3
ESR1
ETS1
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PALS2
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TFAP2A
TNFSF11
TNIP1
TNIP2
TP53BP1
TP53BP2
TRIP4
TSC22D3
TXN
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
Entrez ID
1499
4790
HPRD ID
00286
01238
Ensembl ID
ENSG00000168036
ENSG00000109320
Uniprot IDs
A0A024R2Q3
B4DGU4
P35222
P19838
PDB IDs
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
6M90
6M91
6M92
6M93
6M94
6O9B
6O9C
6WLX
6WNX
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?