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CTNNB1 and PIN1
Data Source:
HPRD
(in vivo, in vitro)
CTNNB1
PIN1
Description
catenin beta 1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Image
GO Annotations
Cellular Component
Euchromatin
Spindle Pole
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Cell Junction
Beta-catenin Destruction Complex
Protein-containing Complex
Protein-DNA Complex
Cell Projection
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Beta-catenin-TCF Complex
Wnt Signalosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Midbody
Ciliary Basal Body
Neuron Projection
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Enzyme Binding
Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Nuclear Hormone Receptor Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
I-SMAD Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Motor Activity
Protein Binding
Beta-catenin Binding
Cis-trans Isomerase Activity
Mitogen-activated Protein Kinase Kinase Binding
GTPase Activating Protein Binding
Tau Protein Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Phosphoprotein Binding
Biological Process
Protein Polyubiquitination
Branching Involved In Blood Vessel Morphogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Neuroblast Proliferation
Cell Adhesion
Wnt Signaling Pathway, Calcium Modulating Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Viral Process
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Regulation Of Centriole-centriole Cohesion
Response To Estradiol
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Protein Sumoylation
Adherens Junction Assembly
Protein Localization To Cell Surface
Hair Cell Differentiation
Entry Of Bacterium Into Host Cell
Detection Of Muscle Stretch
Embryonic Skeletal Limb Joint Morphogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Regulation Of Fibroblast Proliferation
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Histone H3-K4 Methylation
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Endothelial Tube Morphogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Regulation Of Calcium Ion Import
Cell-cell Adhesion
Positive Regulation Of Core Promoter Binding
Beta-catenin-TCF Complex Assembly
Beta-catenin Destruction Complex Disassembly
Midbrain Dopaminergic Neuron Differentiation
Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Neuron Projection Extension
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of DNA-templated Transcription, Initiation
Protein Peptidyl-prolyl Isomerization
Response To Hypoxia
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Cell Cycle
Regulation Of Mitotic Nuclear Division
Regulation Of Gene Expression
Neuron Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Regulation Of Cytokinesis
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Microtubule Polymerization
Synapse Organization
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Cell Motility
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Adherens junctions interactions
Binding of TCF/LEF:CTNNB1 to target gene promoters
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Myogenesis
Myogenesis
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
RHO GTPases activate IQGAPs
Transcriptional Regulation by VENTX
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX3 regulates WNT signaling
ISG15 antiviral mechanism
RHO GTPases Activate NADPH Oxidases
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling
Drugs
Urea
Beta-(2-Naphthyl)-Alanine
3,6,9,12,15,18-HEXAOXAICOSANE
Diseases
Gastric cancer
Colorectal cancer
Endometrial Cancer
Pilomatricoma; Epithelioma calcificans of Malherbe
Thyroid cancer
Hepatocellular carcinoma
GWAS
Bone mineral density (hip) (
27311723
19801982
)
Bone mineral density (total hip) (
29883787
)
Colorectal cancer (
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Lumbar spine bone mineral density (
29499414
)
Refractive error (
32231278
)
Systolic blood pressure (
30224653
)
Sleep duration (
25469926
)
Interacting Genes
187 interacting genes:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARFGEF1
ARHGAP32
ASH2L
AXIN1
AXIN2
BCL3
BCL6
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CDC27
CDC34
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK2
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBIN
ESR1
EZR
FBXW2
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GNA13
GRIK2
GRIN1
GRIN2D
GSK3B
H1-2
HIF1A
HNF1A
HUWE1
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAP3K2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKM
PKP2
PLK1
PPM1A
PRKCG
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RUVBL1
RUVBL2
RXRA
SALL1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SMURF1
SOX1
SOX17
SP1
SPN
SRC
STUB1
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TLE1
TRIM33
TRIM55
TRIM63
TRIP10
TRRAP
UBE2B
UBE2D1
UBE2R2
UBE2S
UBE3A
UHRF2
USP2
USP9X
ZFYVE9
ZIC3
263 interacting genes:
ABI2
ADAMTSL4
ADARB1
AJUBA
AMOT
ANKRD40
AP2A1
APLP1
APP
ARHGEF15
ARID5A
ATCAY
ATN1
ATP5F1B
BAG6
BARD1
BCL11A
BCL2
BCL6
BCLAF1
BRCA1
BRD8
C3orf36
CAPRIN1
CARHSP1
CASP6
CBFA2T3
CBS
CBY2
CCDC153
CCDC184
CCDC33
CCDC6
CCDC88B
CCDC90B
CCNB1
CCNE1
CCNK
CDC25C
CDC27
CDK1
CDK11A
CDK11B
CDK12
CDK2
CDK9
CDKN1B
CENPB
CEP55
CEP76
CHAMP1
CHPF
CNKSR1
COL11A2
CPEB1
CPNE6
CSAD
CSNK2A1
CSNK2A2
CSNK2B
CTNNB1
DAB1
DAB2
DDAH2
DDB1
DDX17
DDX24
DDX3X
DDX5
DEAF1
DHX15
DMPK
DYNC1I1
E2F4
EFS
EFTUD2
EIF3G
EP300
ETV6
EYA2
FAAP20
FADD
FASLG
FHL5
FOS
FOSL1
FOXI1
FOXN1
FOXO4
FOXP2
FRS2
FUCA2
G3BP1
G3BP2
GGA2
GLI1
GMEB2
GOLGA2
GOLGA6L9
GPAA1
GPHN
GPR152
HADHA
HEXIM2
HNRNPC
HNRNPH1
HNRNPK
HNRNPU
HOMEZ
HOXA1
IKZF1
IKZF3
INO80E
JAKMIP2
JUN
KCTD7
KIF20B
KIF5A
KIFC3
KLHL20
KMT2B
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-2
KRTAP5-9
LCN2
LEPR
LRIF1
MAP1S
MAP3K11
MAPT
MCL1
MDFI
MED1
MEOX1
MEOX2
MLLT6
MOCS1
MTFR1
MTUS2
MYF5
MYT1
NAB2
NCKIPSD
NCOA3
NCOR2
NEK6
NELFA
NEUROD4
NFATC2
NONO
NR4A3
NUP35
NUP62
PABPC1
PAX6
PBX1
PDLIM7
PKIB
PKM
PKMYT1
PLAGL2
PLEKHG2
PLK1
PML
PNMA1
POLR2A
PRPF8
PRRC1
PTOV1
PTPN1
QARS1
RAB4A
RAF1
RAI1
RARA
RBBP8
RBBP8NL
RBPMS
RELA
REPS1
RNF208
RNPS1
RPL4
RPS6KB1
SCAI
SCYL1
SELENOV
SFPQ
SGK1
SHKBP1
SMAD3
SNCAIP
SNRNP200
SOCS3
SREK1
SRRM1
SRRM2
SRSF11
SSBP2
SSBP3
SSBP4
SSC5D
STIL
SUPT5H
TAB3
TBC1D4
TCF12
TCF4
TFG
TFPT
THAP7
THRAP3
TLE3
TNIP1
TNS2
TOP2A
TOX3
TP53
TP63
TP73
TRAF1
TRAF2
TRIM27
TRIM59
TRIP6
TRMT2A
TSC2
TSC22D4
TUT1
U2AF2
UBB
UBQLN2
UBQLN4
UBXN2B
UNC119
VIRMA
WEE1
WIZ
WRNIP1
XRCC6
ZBTB14
ZBTB2
ZBTB22
ZBTB42
ZBTB7B
ZBTB9
ZCCHC10
ZMIZ2
ZNF446
ZNF449
ZNF526
ZNF768
ZNF783
Entrez ID
1499
5300
HPRD ID
00286
03031
Ensembl ID
ENSG00000168036
ENSG00000127445
Uniprot IDs
A0A024R2Q3
B4DGU4
P35222
Q13526
PDB IDs
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
6M90
6M91
6M92
6M93
6M94
6O9B
6O9C
6WLX
6WNX
1F8A
1I6C
1I8G
1I8H
1NMV
1NMW
1PIN
1ZCN
2F21
2ITK
2KBU
2KCF
2LB3
2M8I
2M8J
2M9E
2M9F
2M9I
2M9J
2N1O
2Q5A
2RUC
2RUD
2RUQ
2RUR
2XP3
2XP4
2XP5
2XP6
2XP7
2XP8
2XP9
2XPA
2XPB
2ZQS
2ZQT
2ZQU
2ZQV
2ZR4
2ZR5
2ZR6
3I6C
3IK8
3IKD
3IKG
3JYJ
3KAB
3KAC
3KAD
3KAF
3KAG
3KAH
3KAI
3KCE
3NTP
3ODK
3OOB
3TC5
3TCZ
3TDB
3WH0
4GWT
4GWV
4QIB
4TNS
4TYO
4U84
4U85
4U86
5B3W
5B3X
5B3Y
5B3Z
5BMY
5GPH
5UY9
5VTI
5VTJ
5VTK
6DUN
6O33
6O34
6SVC
6SVE
6SVH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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