PCGF5 and RING1

Data Source:
BioGRID (two hybrid)

		PCGF5	RING1
Description		polycomb group ring finger 5	ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Metal Ion Binding	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) Height ( 28552196)	Asthma ( 32296059) Wegener's granulomatosis ( 23740775)
Interacting Genes		10 interacting genes: CBX6 CBX7 CBX8 PCGF1 PHC2 PRMT6 RING1 TRAF2 TRIM8 UBE2D3	34 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 NFKBID PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K YAF2 ZIM3
Entrez ID		84333	6015
HPRD ID		17825	03624
Ensembl ID		ENSG00000180628	ENSG00000204227
Uniprot IDs		Q86SE9	A0A1U9X8F2 Q06587
PDB IDs		4S3O
Enriched GO Terms of Interacting Partners?
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