RING1 and PCGF5

Data Source:
BioGRID (two hybrid)

		RING1	PCGF5
Description		ring finger protein 1	polycomb group ring finger 5
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding Metal Ion Binding
	Biological Process	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Adult body size ( 32376654) Chronotype ( 30696823) Height ( 28552196)
Interacting Genes		34 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 NFKBID PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K YAF2 ZIM3	10 interacting genes: CBX6 CBX7 CBX8 PCGF1 PHC2 PRMT6 RING1 TRAF2 TRIM8 UBE2D3
Entrez ID		6015	84333
HPRD ID		03624	17825
Ensembl ID		ENSG00000204227	ENSG00000180628
Uniprot IDs		A0A1U9X8F2 Q06587	Q86SE9
PDB IDs			4S3O
Enriched GO Terms of Interacting Partners?
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