RING1 and CBX7

Data Source:
HPRD (in vitro, in vivo)

		RING1	CBX7
Description		ring finger protein 1	chromobox 7
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Cytosol PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding
	Biological Process	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Lymphocyte counts ( 32888494 27863252) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Multiple myeloma ( 26007630 23955597) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		34 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 NFKBID PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K YAF2 ZIM3	8 interacting genes: B3GNT5 H3-4 PCGF1 PCGF5 PCGF6 RING1 SUV39H2 ZRANB1
Entrez ID		6015	23492
HPRD ID		03624	12234
Ensembl ID		ENSG00000204227	ENSG00000100307
Uniprot IDs		A0A1U9X8F2 Q06587	A0A024R1Q2 B0QYP2 O95931 Q4PNR6
PDB IDs			2K1B 2L12 2L1B 3GS2 4MN3 5EPJ 6V2R
Enriched GO Terms of Interacting Partners?
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