STK40 and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		STK40	POLA2
Description		serine/threonine kinase 40	DNA polymerase alpha 2, accessory subunit
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Molecular_function DNA Binding Protein Binding
	Biological Process	Respiratory System Process Glycogen Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Neutrophil count ( 32888494)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		7 interacting genes: APP COP1 COPS6 LRRK2 NEDD4L POLA2 SLIRP	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		83931	23649
HPRD ID		11359	10160
Ensembl ID		ENSG00000196182	ENSG00000014138
Uniprot IDs		Q8N2I9	Q14181
PDB IDs		5L2Q	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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