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POLA2 and POLA1
Data Source:
HPRD
(in vivo, in vitro)
POLA2
POLA1
Description
DNA polymerase alpha 2, accessory subunit
DNA polymerase alpha 1, catalytic subunit
Image
GO Annotations
Cellular Component
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Cytosol
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Molecular Function
Molecular_function
DNA Binding
Protein Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
Telomere Maintenance Via Semi-conservative Replication
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Drugs
Dacarbazine
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Acne (severe) (
24927181
)
Serum uric acid levels (
32514006
)
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
33 interacting genes:
AKTIP
APP
ASCC2
ATP5F1C
CPE
CRELD1
DCP2
DDX24
DHX34
EIF6
EZH2
FAM219A
FGFR3
FRZB
HDAC6
HELB
HGH1
IGFBP3
KCNE3
KLF6
LRPAP1
MFHAS1
NR4A1
PARP1
POLA1
PRIM2
PRPF38A
RBM23
SETDB1
SNU13
STK40
ULK2
XPNPEP1
20 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
Entrez ID
23649
5422
HPRD ID
10160
02416
Ensembl ID
ENSG00000014138
ENSG00000101868
Uniprot IDs
Q14181
A6NMQ1
P09884
PDB IDs
2KEB
4E2I
4Y97
5EXR
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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