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CASP3 and NFE2L2
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
CASP3
NFE2L2
Description
caspase 3
nuclear factor, erythroid 2 like 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Death-inducing Signaling Complex
Neuronal Cell Body
Membrane Raft
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Molecular Function
Protease Binding
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Death Receptor Binding
Protein Binding
Peptidase Activity
Phospholipase A2 Activator Activity
Protein-containing Complex Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Biological Process
Luteolysis
Response To Hypoxia
B Cell Homeostasis
Apoptotic DNA Fragmentation
Proteolysis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Axonal Fasciculation
Heart Development
Sensory Perception Of Sound
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To UV
Response To Glucose
Response To X-ray
Regulation Of Macroautophagy
Protein Processing
Cytokine-mediated Signaling Pathway
Hippocampus Development
Neuron Differentiation
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Response To Nicotine
Hippo Signaling
Wound Healing
Response To Drug
Response To Hydrogen Peroxide
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Neuron Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Activated T Cell Proliferation
Response To Antibiotic
Neurotrophin TRK Receptor Signaling Pathway
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Neuron Apoptotic Process
Anterior Neural Tube Closure
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Positive Regulation Of Amyloid-beta Formation
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Viral Process
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Cellular Response To Drug
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Drugs
Pamidronic acid
Acetylsalicylic acid
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
Emricasan
Incadronic acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Glycyrrhizic acid
Diseases
GWAS
Blood protein levels (
28240269
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Kawasaki disease (
33106546
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
157 interacting genes:
ACIN1
ADD1
AFP
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ARNT
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SNRNP70
SOCS5
SOHLH1
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
37 interacting genes:
ATF4
BPTF
CASP1
CASP3
CDH1
CHD6
COPS7A
CREB3
CREBBP
DCAF11
EIF2AK3
GSK3B
JUN
JUND
KDM1A
KEAP1
KPNA3
MAFF
MAFG
MAFK
MAPK7
MAPK8
NCOR2
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
SUMO1
SUMO2
TNNT1
TRIM24
UBE2E2
WAC
Entrez ID
836
4780
HPRD ID
02799
02732
Ensembl ID
ENSG00000164305
ENSG00000116044
Uniprot IDs
P42574
Q16236
PDB IDs
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
4PRY
4PS0
4QTX
4QTY
4QU0
4QU5
4QU8
4QU9
4QUA
4QUB
4QUD
4QUE
4QUG
4QUH
4QUI
4QUJ
4QUL
5I9B
5I9T
5IAB
5IAE
5IAG
5IAJ
5IAK
5IAN
5IAR
5IAS
5IBC
5IBP
5IBR
5IC4
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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