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NFE2L2 and PMF1
Data Source:
HPRD
(two hybrid, in vitro)
NFE2L2
PMF1
Description
nuclear factor, erythroid 2 like 2
polyamine modulated factor 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
MIS12/MIND Type Complex
Condensed Chromosome Kinetochore
Nuclear MIS12/MIND Complex
Nucleoplasm
Transcription Regulator Complex
Golgi Apparatus
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Transcription Coactivator Activity
Protein Binding
Leucine Zipper Domain Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Viral Process
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Cellular Response To Drug
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Transcription By RNA Polymerase II
Cell Cycle
Chromosome Segregation
Positive Regulation Of Transcription, DNA-templated
Cell Division
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Estimated glomerular filtration rate (
30604766
)
Intracerebral hemorrhage (
24656865
)
Ischemic stroke (
29531354
)
Ischemic stroke (small-vessel) (
29531354
)
Longevity (age >99th survival percentile) (
31413261
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Non-lobar intracerebral hemorrhage (MTAG) (
31430377
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Stroke (
29531354
)
White matter hyperintensity burden (
25663218
)
Interacting Genes
37 interacting genes:
ATF4
BPTF
CASP1
CASP3
CDH1
CHD6
COPS7A
CREB3
CREBBP
DCAF11
EIF2AK3
GSK3B
JUN
JUND
KDM1A
KEAP1
KPNA3
MAFF
MAFG
MAFK
MAPK7
MAPK8
NCOR2
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
SUMO1
SUMO2
TNNT1
TRIM24
UBE2E2
WAC
24 interacting genes:
BICD2
CEP126
COPS6
COPS7A
COPS7B
CRMP1
DSN1
EFHC1
FBXO28
GDF9
GIT1
HSP90AA1
KDM1A
MED31
MESD
MIS12
NFE2L2
PTN
SHC3
SUGT1
TBC1D21
TCP10L
TSNAX
USHBP1
Entrez ID
4780
11243
HPRD ID
02732
11441
Ensembl ID
ENSG00000116044
ENSG00000160783
Uniprot IDs
Q16236
Q6P1K2
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
5LSJ
5LSK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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