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NFE2L2 and KDM1A
Data Source:
BioGRID
(two hybrid)
NFE2L2
KDM1A
Description
nuclear factor, erythroid 2 like 2
lysine demethylase 1A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
DNA Repair Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
P53 Binding
Chromatin Binding
Protein Binding
Transcription Factor Binding
Oxidoreductase Activity
Enzyme Binding
Nuclear Receptor Coactivator Activity
Demethylase Activity
Histone Demethylase Activity
Histone Demethylase Activity (H3-K4 Specific)
Histone Demethylase Activity (H3-K9 Specific)
Histone Demethylase Activity (H3-dimethyl-K4 Specific)
Telomeric DNA Binding
MRF Binding
Flavin Adenine Dinucleotide Binding
Androgen Receptor Binding
Telomeric Repeat-containing RNA Binding
Promoter-specific Chromatin Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Viral Process
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Cellular Response To Drug
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Alternative MRNA Splicing, Via Spliceosome
Positive Regulation Of Neuroblast Proliferation
Regulation Of Transcription By RNA Polymerase II
Protein Demethylation
Blood Coagulation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Neuron Projection Development
Cerebral Cortex Development
Negative Regulation Of Protein Binding
Histone H3-K9 Demethylation
Positive Regulation Of Histone Ubiquitination
Cellular Response To UV
Histone H3-K4 Demethylation
Positive Regulation Of Chromatin Binding
Neuron Maturation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Size
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Guanine Metabolic Process
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Muscle Cell Development
Response To Fungicide
Cellular Response To CAMP
Cellular Response To Gamma Radiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Cellular Protein Localization
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Pathways
HDACs deacetylate histones
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Gamma glutamyl transferase levels (
29403010
)
Global electrical heterogeneity phenotypes (
29622589
)
Pulse pressure (
27841878
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
37 interacting genes:
ATF4
BPTF
CASP1
CASP3
CDH1
CHD6
COPS7A
CREB3
CREBBP
DCAF11
EIF2AK3
GSK3B
JUN
JUND
KDM1A
KEAP1
KPNA3
MAFF
MAFG
MAFK
MAPK7
MAPK8
NCOR2
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
SUMO1
SUMO2
TNNT1
TRIM24
UBE2E2
WAC
265 interacting genes:
AKAP9
ANKEF1
ANKRD23
AP1G2
AR
ARHGAP15
ARHGAP29
ASB10
ASB3
ASCC2
ATP5MF
ATP6V1B1
BAHD1
BAIAP2
BATF
BCAT1
BIRC2
BLZF1
BMP3
BRCA1
C18orf54
C4orf17
C8orf48
C8orf74
CAGE1
CARD10
CCDC121
CCDC14
CCDC172
CCDC33
CCDC74A
CCDC74B
CCDC90B
CDC23
CDC5L
CDCA4
CDCA5
CENPQ
CEP162
CEP57
CEP70
CEP76
CFAP100
COIL
CRBN
CRLF3
CSNK2A1
CSNK2A2
CTBP1
DBF4B
DNAAF4
DNAJA3
DNTTIP1
E2F1
ECI2
ELOF1
EXOC1
EXOC7
FAM161A
FAM204A
FAM9A
FIGNL1
FYCO1
FYN
GABPB2
GAS8
GATA3
GCC1
GDF9
GLYR1
GOLGA2
GOLGA6A
GPATCH2L
GSK3B
GSTCD
GTPBP2
H3-4
H3-5
H3C1
H3C14
HAUS1
HAUS3
HAUS6
HDAC1
HESX1
HOMER3
HOXA1
ID2
IFI35
IGFBP4
IK
IKBIP
IL16
IMMT
INSM1
INTS2
ISL1
ITGB3BP
ITSN2
JRK
KANSL1
KASH5
KDM5B
KIAA0408
KIFC3
KLC3
KLF3
KLHDC4
KRT15
KRT17
KRT19
KRT222
KRT31
KRT33B
KRT35
KRT38
KRT39
KRT40
KRT6A
KRT6B
KRT7
L3MBTL3
LENG8
LINC02875
LOXL4
LZTS1
MALT1
MBD3
MBD4
MCPH1
MCRS1
METTL27
MLC1
MNS1
MTA3
MTF2
MTMR9
MTO1
MYC
MYLIP
NBPF15
NBPF26
NDUFA8
NDUFS1
NECAB2
NEFL
NF2
NFE2L2
NMI
NOSTRIN
NR1H2
NR1H3
NR2C2
NR2E1
NRBF2
ODAD3
OFCC1
OIP5
OPA3
OTUB1
PBX4
PDCD5
PDE4DIP
PEX7
PFDN5
PHC2
PHF19
PHF20L1
PHF21A
PMF1
PNKP
PPARD
PPM1D
PPP1R12A
PRDM1
PRIM2
PSMC1
PSMC3
PTEN
RASSF1
RASSF2
RASSF3
RASSF8
RCOR1
RCOR3
RIOK1
RNF10
RNF168
RPRD1A
SAMD3
SEPTIN6
SERGEF
SETDB1
SF3B2
SH3GLB2
SLU7
SMAD9
SMARCD1
SMN1
SNF8
SNX15
SOCS6
SPATA22
SPATA24
SPICE1
SPRY2
SPSB1
SPZ1
SRGAP3
SSX2IP
STAT3
STX11
STX19
SUMO2
SUV39H1
TACC1
TADA3
TAL1
TDO2
TEDC2
TERF1
TEX35
TEX9
TFIP11
TLE5
TMEM266
TNFAIP1
TNNT2
TP53
TP53BP1
TP53BP2
TRAF4
TRIM39
TRIM54
TSACC
TSC1
TTC23
TTC33
UBA3
UBASH3B
UBE2I
UCHL5
UNC119
UNKL
USP28
USP7
VPS11
VPS37A
VPS37B
WASHC3
WDR83
ZBED1
ZBTB24
ZBTB39
ZCCHC17
ZFP28
ZNF280A
ZNF333
ZNF436
ZNF451
ZNF480
ZNF581
ZNF641
ZNF71
ZNF829
Entrez ID
4780
23028
HPRD ID
02732
09800
Ensembl ID
ENSG00000116044
ENSG00000004487
Uniprot IDs
Q16236
O60341
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
2COM
2DW4
2EJR
2H94
2HKO
2IW5
2L3D
2UXN
2UXX
2V1D
2X0L
2XAF
2XAG
2XAH
2XAJ
2XAQ
2XAS
2Y48
2Z3Y
2Z5U
3ABT
3ABU
3ZMS
3ZMT
3ZMU
3ZMV
3ZMZ
3ZN0
3ZN1
4BAY
4CZZ
4KUM
4UV8
4UV9
4UVA
4UVB
4UVC
4UXN
4XBF
5AFW
5H6Q
5H6R
5IT3
5L3B
5L3C
5L3D
5L3E
5L3F
5L3G
5LBQ
5LGN
5LGT
5LGU
5LHG
5LHH
5LHI
5X60
5YJB
6E1F
6K3E
6KGK
6KGL
6KGM
6KGN
6KGO
6KGP
6KGQ
6KGR
6NQM
6NQU
6NR5
6S35
6TE1
6VYP
6W4K
7JJL
7JJM
7JK7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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