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FZD4 and ARRB2
Data Source:
HPRD
(in vivo)
FZD4
ARRB2
Description
frizzled class receptor 4
arrestin beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Dendrite
Clathrin-coated Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
Wnt-protein Binding
Cytokine Binding
PDZ Domain Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Protein Homodimerization Activity
Wnt-activated Receptor Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
G Protein-coupled Receptor Binding
Signaling Receptor Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Type 1 Angiotensin Receptor Binding
D1 Dopamine Receptor Binding
Follicle-stimulating Hormone Receptor Binding
Type 2A Serotonin Receptor Binding
Platelet Activating Factor Receptor Binding
Identical Protein Binding
Protein Kinase B Binding
Protein-containing Complex Binding
Mitogen-activated Protein Kinase Binding
14-3-3 Protein Binding
Arrestin Family Protein Binding
Biological Process
Vasculogenesis
G Protein-coupled Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell-substrate Adhesion
Wnt Signaling Pathway
Cytokine-mediated Signaling Pathway
Neuron Differentiation
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Locomotion Involved In Locomotory Behavior
Substrate Adhesion-dependent Cell Spreading
Extracellular Matrix-cell Signaling
Non-canonical Wnt Signaling Pathway
Progesterone Secretion
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Retina Vasculature Morphogenesis In Camera-type Eye
Cerebellum Vasculature Morphogenesis
Retinal Blood Vessel Morphogenesis
Cellular Response To Retinoic Acid
Negative Regulation Of Canonical Wnt Signaling Pathway
Norrin Signaling Pathway
Positive Regulation Of Neuron Projection Arborization
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Positive Regulation Of Receptor Internalization
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Brain Development
Adult Walking Behavior
Positive Regulation Of Gene Expression
Protein Transport
Protein Ubiquitination
Protein Deubiquitination
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Toll-like Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Follicle-stimulating Hormone Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Excitatory Postsynaptic Potential
Cell Chemotaxis
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Class B/2 (Secretin family receptors)
Ca2+ pathway
Ca2+ pathway
Asymmetric localization of PCP proteins
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD4
Signaling by RNF43 mutants
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS
Hepatocellular carcinoma in hepatitis B infection (
26870257
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
7 interacting genes:
ARRB2
BAG6
DLG1
DLG2
DLG4
DVL2
MAGI3
52 interacting genes:
ADRB2
AGTR1
AP1B1
AP2M1
ARF6
AVPR2
C5AR1
CDC42
CLTC
CSNK2A1
CSNK2A2
CXCR4
CYTH2
DLG4
DVL2
EGFR
FLNA
FZD4
GRK2
HCRTR1
HIPK3
HTR2C
ITCH
LHCGR
LIMK1
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK9
MDM2
MED8
NDUFS7
NFKBIA
NTS
NTSR1
OPRD1
OXER1
OXTR
PDE4D
PRKN
PTAFR
PTGDS
RAF1
RALGDS
RHO
SLC9A5
SMARCC2
STC2
TGFBR3
TRH
UBC
Entrez ID
8322
409
HPRD ID
05203
00147
Ensembl ID
ENSG00000174804
ENSG00000141480
Uniprot IDs
Q9ULV1
K7ENA6
P32121
Q59EM5
Q68DZ5
PDB IDs
5BPB
5BPQ
5BQC
5BQE
5CL1
5CM4
5UWG
6BD4
6NE1
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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