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FZD4
Description
frizzled class receptor 4
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Dendrite
Clathrin-coated Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Glutamatergic Synapse
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
Wnt-protein Binding
Cytokine Binding
PDZ Domain Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Protein Homodimerization Activity
Wnt-activated Receptor Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Biological Process
Vasculogenesis
G Protein-coupled Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell-substrate Adhesion
Wnt Signaling Pathway
Cytokine-mediated Signaling Pathway
Neuron Differentiation
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Locomotion Involved In Locomotory Behavior
Substrate Adhesion-dependent Cell Spreading
Extracellular Matrix-cell Signaling
Non-canonical Wnt Signaling Pathway
Progesterone Secretion
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Retina Vasculature Morphogenesis In Camera-type Eye
Cerebellum Vasculature Morphogenesis
Retinal Blood Vessel Morphogenesis
Cellular Response To Retinoic Acid
Negative Regulation Of Canonical Wnt Signaling Pathway
Norrin Signaling Pathway
Positive Regulation Of Neuron Projection Arborization
Cellular Response To Leukemia Inhibitory Factor
Pathways
Class B/2 (Secretin family receptors)
Ca2+ pathway
Ca2+ pathway
Asymmetric localization of PCP proteins
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD4
Signaling by RNF43 mutants
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS
Hepatocellular carcinoma in hepatitis B infection (
26870257
)
Interacting Genes
7 interacting genes:
ARRB2
BAG6
DLG1
DLG2
DLG4
DVL2
MAGI3
Entrez ID
8322
HPRD ID
05203
Ensembl ID
ENSG00000174804
Uniprot IDs
Q9ULV1
PDB IDs
5BPB
5BPQ
5BQC
5BQE
5CL1
5CM4
5UWG
6BD4
6NE1
Enriched GO Terms of Interacting Partners
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