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ARRB2 and OXTR
Data Source:
HPRD
(in vivo)
ARRB2
OXTR
Description
arrestin beta 2
oxytocin receptor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Adherens Junction
Apical Plasma Membrane
Molecular Function
G Protein-coupled Receptor Binding
Signaling Receptor Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Type 1 Angiotensin Receptor Binding
D1 Dopamine Receptor Binding
Follicle-stimulating Hormone Receptor Binding
Type 2A Serotonin Receptor Binding
Platelet Activating Factor Receptor Binding
Identical Protein Binding
Protein Kinase B Binding
Protein-containing Complex Binding
Mitogen-activated Protein Kinase Binding
14-3-3 Protein Binding
Arrestin Family Protein Binding
G Protein-coupled Receptor Activity
Oxytocin Receptor Activity
Vasopressin Receptor Activity
Peptide Hormone Binding
Peptide Binding
Biological Process
Negative Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Positive Regulation Of Receptor Internalization
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Brain Development
Adult Walking Behavior
Positive Regulation Of Gene Expression
Protein Transport
Protein Ubiquitination
Protein Deubiquitination
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Toll-like Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Follicle-stimulating Hormone Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Excitatory Postsynaptic Potential
Cell Chemotaxis
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Cardiac Muscle Cell Differentiation
Suckling Behavior
Response To Amphetamine
Regulation Of Systemic Arterial Blood Pressure By Vasopressin
Muscle Contraction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Heart Development
Female Pregnancy
Lactation
Memory
Positive Regulation Of Norepinephrine Secretion
Telencephalon Development
Sleep
Positive Regulation Of Synaptic Transmission, GABAergic
Response To Estradiol
Response To Progesterone
Response To Anoxia
Response To Cytokine
Social Behavior
Response To Cocaine
Response To Drug
Maternal Behavior
Sperm Ejaculation
Eating Behavior
Response To Peptide Hormone
Estrous Cycle
Positive Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Digestive Tract Development
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Maternal Process Involved In Parturition
Positive Regulation Of Penile Erection
Negative Regulation Of Gastric Acid Secretion
ERK1 And ERK2 Cascade
Positive Regulation Of Uterine Smooth Muscle Contraction
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Vasopressin-like receptors
G alpha (q) signalling events
Drugs
Oxytocin
Carbetocin
Atosiban
Relcovaptan
Diseases
GWAS
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
White blood cell count (
32888494
)
Caudate activity during reward (
28927378
)
Chronotype (
30696823
)
Depression and alcohol dependence (
22064162
)
Liver fibrosis severity in HIV/hepatitis C co-infection (
27339598
)
Morning person (
30696823
)
Interacting Genes
52 interacting genes:
ADRB2
AGTR1
AP1B1
AP2M1
ARF6
AVPR2
C5AR1
CDC42
CLTC
CSNK2A1
CSNK2A2
CXCR4
CYTH2
DLG4
DVL2
EGFR
FLNA
FZD4
GRK2
HCRTR1
HIPK3
HTR2C
ITCH
LHCGR
LIMK1
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK9
MDM2
MED8
NDUFS7
NFKBIA
NTS
NTSR1
OPRD1
OXER1
OXTR
PDE4D
PRKN
PTAFR
PTGDS
RAF1
RALGDS
RHO
SLC9A5
SMARCC2
STC2
TGFBR3
TRH
UBC
18 interacting genes:
ALAS1
ARRB2
ASH1L
AVP
CD81
CYFIP2
EMC10
FSCN1
GPRASP1
LCNL1
MVB12A
OXT
PSMA7
SIRT2
THOC5
TMEM161A
TSPAN7
YIPF3
Entrez ID
409
5021
HPRD ID
00147
01328
Ensembl ID
ENSG00000141480
ENSG00000180914
Uniprot IDs
K7ENA6
P32121
Q59EM5
Q68DZ5
B2R9L7
P30559
PDB IDs
6TPK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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