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H3-4 and NCOA3
Data Source:
BioGRID
(enzymatic study, enzymatic study)
H3-4
NCOA3
Description
H3.4 histone
nuclear receptor coactivator 3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
RNA Polymerase II Complex Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Nuclear Receptor Binding
Nuclear Receptor Coactivator Activity
Nuclear Hormone Receptor Binding
Thyroid Hormone Receptor Binding
Protein Dimerization Activity
Protein N-terminus Binding
Disordered Domain Specific Binding
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Telomere Capping
Histone Acetylation
Cellular Response To Hormone Stimulus
Receptor Transactivation
Cell Dedifferentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Division
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
Estrogen-dependent gene expression
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Osteoarthritis (hip) (
23989986
)
Response to treatment for acute lymphoblastic leukemia (
19176441
)
Interacting Genes
198 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BIRC5
BMI1
BPTF
BRD7
C17orf49
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DIDO1
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPK
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2A
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
82 interacting genes:
ABL1
ANKRD11
AR
ARNT2
ATAD2
BABAM2
BMP6
BMP7
BRCA1
CCND1
CDKN3
CHUK
CREBBP
CSNK1E
DCTN6
DDX17
DDX5
E2F1
EP300
ESR1
ESR2
ESRRA
ESRRB
ETV1
FOS
GSK3B
GTF2B
H3-4
H4-16
HNF1A
IKBKB
IKBKG
IQCK
JUN
KAT2B
MAPK1
MAPK14
MAPK8
MMS19
MN1
MRTFA
MRTFB
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR1I2
NR1I3
NR2F1
NR3C1
NR4A1
NR5A2
PGR
PIN1
PPARA
PPARD
PPARG
PRKCZ
PRMT1
PSMB9
PSME3
RARA
RARB
RARG
RELA
RXRA
RXRB
SLC22A2
SMARCE1
SPOP
SUFU
SUMO1
TBP
THRB
TP53
TP53BP1
VDR
YWHAH
YWHAQ
Entrez ID
8290
8202
HPRD ID
04156
03570
Ensembl ID
ENSG00000168148
ENSG00000124151
Uniprot IDs
Q16695
Q59EE8
Q9Y6Q9
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
1KBH
3L3X
3L3Z
6ES7
6SQC
Enriched GO Terms of Interacting Partners
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